Immunogen sequence: PPPPLTLRMR RYADAIFTNS YRKVLGQLSA RKLLQDIMSR QQGESNQERG ARARLGRQVD SMWAEQKQME LESILVALLQ KHRNSQG; Positive Samples: Raji, HL-60, U-937, Mouse liver
This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
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Protein Aliases: GHRH; GRF; Growth hormone-releasing factor; Growth hormone-releasing hormone; Sermorelin; Somatocrinin; Somatoliberin; Somatorelin
Gene Aliases: GHRF; GHRH; GRF; INN