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Product Details
PA5-92408
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GHRH (NP_0665671)
Conjugate
Form
Liquid
Concentration
1.3 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806480
Product Specific Information
Positive Samples: Raji, HL-60, U-937, Mouse liver
Immunogen sequence: FTNSYRKVLG QLSARKLLQ
Target Information
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GHRH; GRF; Growth hormone-releasing factor; Growth hormone-releasing hormone; MGC119781; OTTHUMP00000030915; sermorelin; Somatocrinin; Somatoliberin; Somatorelin
Gene Aliases: GHRF; GHRH; GRF; INN
UniProt ID: (Human) P01286, (Rat) P09916, (Mouse) P16043
Entrez Gene ID: (Human) 2691, (Rat) 29446, (Mouse) 14601
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
cAMP-mediated signaling
adenohypophysis development
growth hormone secretion
positive regulation of cAMP biosynthetic process
response to food
positive regulation of multicellular organism growth
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of circadian sleep/wake cycle, REM sleep
positive regulation of growth hormone secretion
response to hypoxia
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
negative regulation of cardiac muscle cell apoptotic process
positive regulation of cAMP metabolic process
circadian sleep/wake cycle, non-REM sleep
response to leptin
positive regulation of transcription, DNA-templated
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of hormone secretion
cellular response to interleukin-6
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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