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GHRPR/Ghrelin Receptor/GHS-R1 Polyclonal Antibody
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Product Details
BS-11529R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Ghrelin Receptor, amino acids 75-135.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Growth hormone secretagogue receptor 1a (GHSR) is a member of the G-protein coupled receptor family. GHSR may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations to the gene can cause isolated partial growth hormone deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G-protein coupled receptor; GH-releasing peptide receptor; Ghrelin receptor; GHRP; Ghrp receptor; GHS receptor; GHS-R; Growth hormone secretagogue receptor type 1
Gene Aliases: C530020I22Rik; GHDP; GHS-R1a; GHSR; GHSR-1a
UniProt ID: (Human) Q92847, (Mouse) Q99P50, (Rat) O08725
Entrez Gene ID: (Human) 2693, (Mouse) 208188, (Rat) 84022
growth hormone secretagogue receptor activity
G-protein coupled receptor activity
protein binding
growth hormone-releasing hormone receptor activity
peptide hormone binding
hormone binding
identical protein binding
signal transducer activity
growth hormone receptor binding
G-protein coupled receptor
G-protein coupled receptor internalization
signal transduction
G-protein coupled receptor signaling pathway
spermatogenesis
female pregnancy
learning or memory
actin polymerization or depolymerization
adult feeding behavior
response to hormone
hormone-mediated signaling pathway
negative regulation of norepinephrine secretion
peptide hormone secretion
growth hormone secretion
response to food
negative regulation of appetite
positive regulation of appetite
response to follicle-stimulating hormone
response to estradiol
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
cellular response to insulin stimulus
cellular response to hormone stimulus
ghrelin secretion
positive regulation of multicellular organism growth
regulation of hindgut contraction
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of fatty acid metabolic process
positive regulation of growth
negative regulation of insulin secretion
decidualization
insulin-like growth factor receptor signaling pathway
negative regulation of inflammatory response
regulation of synapse assembly
regulation of transmission of nerve impulse
regulation of growth hormone secretion
regulation of feeding behavior
response to growth hormone
cellular response to lipopolysaccharide
response to dexamethasone
negative regulation of locomotion involved in locomotory behavior
cellular response to thyroid hormone stimulus
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
postsynaptic modulation of chemical synaptic transmission
regulation of postsynapse organization
positive regulation of small intestinal transit
response to L-glutamate
positive regulation of sprouting angiogenesis
positive regulation of eating behavior
positive regulation of small intestine smooth muscle contraction
regulation of gastric motility
positive regulation of vascular endothelial cell proliferation
cellular response to insulin-like growth factor stimulus
negative regulation of macrophage apoptotic process
negative regulation of tumor necrosis factor biosynthetic process
negative regulation of interleukin-6 biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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