Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey, Marmoset (100%).
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a.
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Protein Aliases: GH secretagogue receptor; GH-releasing peptide receptor; Ghrelin receptor; GHRP; Ghrp receptor; GHS receptor; GHS-R; GHSR; Growth hormone secretagogue receptor type 1
Gene Aliases: GHDP; GHSR
UniProt ID: (Human) Q92847
Entrez Gene ID: (Human) 2693