The TSC22 domain family member 3 protein (TSC22D3) is a leucine zipper protein that functions as a transcriptional regulator. The expression of TSC22D3 is stimulated by glucocorticoids and IL-10 and is thought to play a key role in the anti-inflammatory and immunosuppressive effects of these molecules. TSC22D3 can physically interact with and inhibit the activities of key inflammatory signaling mediators such NF-Kappa-B and AP-1. TSC22D3 functions as a transcriptional co-activator for various nuclear receptors and NF-Kappa-B. It has also been shown to be involved in the differentiation of mesenchymal stem cells towards osteoblasts and bone formation.
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Protein Aliases: delta sleep inducing peptide, immunoreactor; Delta sleep-inducing peptide immunoreactor; DSIP-immunoreactive leucine zipper protein; DSIP-immunoreactive peptide; DSIPI; GILZ; Glucocorticoid-induced leucine zipper protein; hDIP; long glucocorticoid-induced leucine zipper protein; Protein DIP; Tilz3; TSC-22 related protein; TSC-22-like protein; TSC-22-related protein; TSC-22R; TSC22 domain family 3; TSC22 domain family protein 3; TSC22 domain family, member 3; TSC22-related inducible leucine zipper 3; TSC22-related-inducible leucine zipper 3; TSC22D3
Gene Aliases: DIP; Dsip1; DSIPI; GILZ; Tilz3; TSC-22R; TSC22D3
Molecular Function: transcription factor