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GIPR Polyclonal Antibody
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Product Details
BS-13292R
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GIPR, amino acids 21-120.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gastric inhibitory peptide receptor; Gastric inhibitory polypeptide receptor; GIP receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor
Gene Aliases: GIP-R; Gippr; GIPR; Gm1081; Gm160; PGQTL2; RATGIPPR
UniProt ID: (Human) P48546, (Mouse) Q0P543, (Rat) P43219
Entrez Gene ID: (Human) 2696, (Mouse) 381853, (Rat) 25024
transmembrane signaling receptor activity
G-protein coupled receptor activity
protein binding
G-protein coupled peptide receptor activity
gastric inhibitory peptide receptor activity
peptide hormone binding
glucagon family peptide binding
signal transducer activity
receptor activity
transmembrane signal receptor
desensitization of G-protein coupled receptor protein signaling pathway
generation of precursor metabolites and energy
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
response to nutrient
response to glucose
endocrine pancreas development
positive regulation of insulin secretion
gastric inhibitory peptide signaling pathway
response to axon injury
regulation of insulin secretion
response to calcium ion
response to fatty acid
neuropeptide signaling pathway
positive regulation of cAMP biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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