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Invitrogen
GKN1 Polyclonal Antibody
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FIGURE: 1 / 1
GKN1 Antibody (PA5-23309) in WB
Western blot analysis of GKN1 in human stomach tissue lysate. Samples were incubated in GKN1 polyclonal antibody (Product # PA5-23309) using a dilution of 1.0 µg/mL, 1.0 µg/mL and 0.5 µg/mL, respectively followed by a goat anti-rabbit Ig HRP secondary antibody. PicoTect ECL substrate solution was used for this test.
Product Details
PA5-23309
Product Specifications
Species Reactivity
Horse,
Human,
Non-human primate,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
The portions of amino acids range between 100-150 of human GKN1.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The amino acid sequence used as immunogen is 100% homologous in chimpanzee and dog, 94% homologous in mouse and cow, 88% homologous in rat and 77% homologous in chicken.
Target Information
Gastrokine 1, also known as GKN1 and CA11, is a 185 amino acid containing secreted protein belonging to the gastrokine family with a BRICHOS domain and an asn-rich region. GKN1 (also known as an antioncogene) is reported to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. Differential display of normal and cancerous gastric tissue suggested that this protein is predominantly expressed in stomach and the expression is down-regulated to considerable frequency in cancer tissue or gastric cancer cell lines examined. This extra cellular protein is co-secreted with mucins and is a signaling growth factor with mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 18 kDa antrum mucosa protein; AMP-18; Amp18; gastrokine; BRICHOS domain containing 1; Gastrokine-1; Protein CA11
Gene Aliases: AMP-18; AMP18; BRICD1; CA11; FOV; foveolin; GKN1; UNQ489/PRO1005
UniProt ID: (Pig) Q8HYA9, (Human) Q9NS71
Entrez Gene ID: (Pig) 100502561, (Human) 56287, (Horse) 100061374
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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