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Invitrogen
GLDC Polyclonal Antibody
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FIGURE: 1 / 5
GLDC Antibody (PA5-26504) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of Hep G2 (Lane 1), Caco-2 (Lane 2), tissue extracts of Mouse Liver (Lane 3) and Rat Liver (Lane 4). The blot was probed with Anti-GLDC Polyclonal Antibody (Product # PA5-26504, 1:1,000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4,000 dilution). A 112 kDa band corresponding to GLDC was observed across the cell lines and tissues tested. A non speci... View More
Product Details
PA5-26504
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 49-77 amino acids from the N-terminal region of human GLDC
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycine cleavage system P protein; glycine cleavage system protein P; Glycine decarboxylase; glycine decarboxylase P-protein; Glycine dehydrogenase (aminomethyl-transferring); Glycine dehydrogenase (decarboxylating), mitochondrial; glycine dehydrogenase [decarboxylating], mitochondrial; nonketotic hyperglycinemia; RP11-472F14.1; unnamed protein product
Gene Aliases: D030049L12Rik; D19Wsu57e; GCE; GCE1; GCSP; GLDC; HYGN1
UniProt ID: (Human) P23378, (Mouse) Q91W43
Entrez Gene ID: (Human) 2731, (Mouse) 104174
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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