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Product Details
26466-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GLE1 Fusion Protein Ag24208 (1-118 aa encoded by BC030012)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPSEGRCWE TLKALRSSDK GRLCYYRDWL LRREDVLEEC MSLPKLSSYS GWVVEHVLPH MQENQPLSET SPSSTSASAL DQPSFVPKSP DASSAFSPAS PATPNGTKGK DESQHTESM (1-118 aa encoded by BC030012 )
Target Information
The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GLE1 RNA export mediator; GLE1 RNA export mediator homolog; GLE1-like protein; GLE1-like, RNA export mediator; hGLE1; mRNA export factor GLE1; Nucleoporin GLE1
Gene Aliases: GLE1; GLE1L; hGLE1; LCCS; LCCS1
UniProt ID: (Human) Q53GS7
Entrez Gene ID: (Human) 2733
Performance Guarantee
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