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GLE1 Polyclonal Antibody
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FIGURE: 1 / 1
GLE1 Antibody (BS-13371R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat testis; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with GLE1 Polyclonal Antibody, Unconjugated (bs-13371R) at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB... View More
Product Details
BS-13371R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GLE1, amino acids 611-698.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GLE1 RNA export mediator; GLE1 RNA export mediator homolog; GLE1 RNA export mediator-like (yeast; GLE1-like protein; GLE1-like, RNA export mediator; hGLE1; mRNA export factor GLE1; Nucleoporin GLE1; similar to Saccharomyces cerevisiae mRNA export factor Gle1p; unnamed protein product
Gene Aliases: 4933405K21Rik; AA553313; CAAHC; CAAHD; GLE1; GLE1L; hGLE1; LCCS; LCCS1
UniProt ID: (Human) O75458, (Mouse) Q8R322, (Rat) Q4KLN4
Entrez Gene ID: (Human) 2733, (Mouse) 74412, (Rat) 362098
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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