Recommended positive controls: A549, H1299, MCF-7.
Predicted reactivity: Mouse (86%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Glis1 (Gli similar 1) is also known as Gli related Kruppel-like zinc finger 1 and is encoded by the Glis1 gene located on chromosome 1 in humans. It belongs to the Kruppel-like zinc finger family of proteins that constitute mainly of transcription factors and is hence studied for its role in target gene activation and repression, specifically during embryonic development. Glis1 contains five tandem zinc finger motifs, which is the region at which it shares close homology to Glis2 and Glis 3. More recent studies on Glis1 show its interaction with Oct 3/4, Sox2 and KLF4 in efficient generation of iPSC.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
Protein Aliases: GLI-similar 1; GLIS1; Zinc finger protein GLIS1
Gene Aliases: GLIS1
UniProt ID: (Human) Q8NBF1
Entrez Gene ID: (Human) 148979
Molecular Function: DNA-binding transcription factor