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Invitrogen
GLRA1/GLRA2 Polyclonal Antibody
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Product Details
PA1-84890
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the N-terminal region of rat glycine receptor alpha 1 subunit.
Conjugate
Form
Lyophilized
Amount
200 µg
Purification
Affinity chromatography
Storage buffer
Ammonium bicarbonate
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-84890 detects a band at ~48 kDa in rat spinal cord lysates.
Reconstitute with 0.1 mL PBS. For long term storage, the addition of 0.09% sodium azide is recommended. Prior to reconstitution, store at 4°C. After reconstitution, store undiluted at -20°C, avoiding freeze/thaw cycles.
Rabbit anti glycine receptor recognizes an epitope within the N-terminal region (NT) of glycine receptor alpha 1 and alpha 2 subunits.
Target Information
Glycine receptors are members of the ligand-gated ion channel superfamily, which mediate fast inhibitory neurotransmission. The receptors are pentameric membrane proteins which form chloride channels. Binding of glycine to its receptor produces an increase in chloride conductance and membrane hyperpolarisation. Four genes encoding glycine receptor alpha subunits have been identified, together with a single beta polypeptide. Each subunit consists of a large extracellular N-terminal region, four transmembrane domains, and a large cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GLRA2; Glycine receptor 48 kDa subunit; glycine receptor alpha 2 subunit; Glycine receptor alpha 2 subunit (glycine receptor, neonatal); Glycine receptor strychnine-binding subunit; Glycine receptor subunit alpha-1; Glycine receptor subunit alpha-2; glycine receptor, alpha 1 subunit; glycine receptor, alpha 2 subunit; glycine receptor, alpha-2 polypeptide; ligand-gated chloride channel; unnamed protein product
Gene Aliases: GLR; GLRA1; GLRA2; Glyr; GLYRA1; HKPX1; MRXSP; nmf11; oscillator; ot; RNNEOGLY; spasmodic; spd; STHE
UniProt ID: (Human) P23415, (Human) P23416, (Mouse) Q64018, (Rat) P07727, (Rat) P22771, (Mouse) Q7TNC8
Entrez Gene ID: (Human) 2741, (Human) 2742, (Mouse) 14654, (Rat) 25674, (Rat) 24397, (Mouse) 237213
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
excitatory extracellular ligand-gated ion channel activity
chloride channel activity
protein binding
zinc ion binding
glycine binding
extracellular-glycine-gated chloride channel activity
transmitter-gated ion channel activity
taurine binding
identical protein binding
metal ion binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
glycine-gated chloride ion channel activity
extracellular-glycine-gated ion channel activity
ligand-gated ion channel
startle response
regulation of respiratory gaseous exchange by neurological system process
ion transport
chloride transport
muscle contraction
neuropeptide signaling pathway
chemical synaptic transmission
acrosome reaction
visual perception
adult walking behavior
neuronal action potential
ion transmembrane transport
regulation of membrane potential
regulation of respiratory gaseous exchange
neuromuscular process controlling posture
neuromuscular process
negative regulation of transmission of nerve impulse
synaptic transmission, glycinergic
righting reflex
excitatory postsynaptic potential
inhibitory postsynaptic potential
cellular response to amino acid stimulus
cellular response to zinc ion
cellular response to ethanol
response to alcohol
regulation of presynaptic membrane potential
chloride transmembrane transport
positive regulation of acrosome reaction
modulation of synaptic transmission
regulation of postsynaptic membrane potential
action potential
transport
anion transport
protein homooligomerization
protein heterooligomerization
synapse assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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