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Product Details
PA5-21673
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 216 of Glycine Receptor alpha 2 (Uniprot ID#P23416)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_11153055
Product Specific Information
Recommended positive controls: 293T, A431, HepG2, mouse brain.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (95%), Rhesus Monkey (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Glycine is an inhibitory neurotransmitter in the central nervous system. The glycine receptor (GlyR) is a member of the nicotinic acetylcholine receptor of ligand-gated ion channels. This receptor has important roles in a variety of physiological processes, especially in mediating inhibitory neurotransmission in the spinal cord and brain stem. GlyR is a pentameric receptor comprised of alpha and beta subunits. Four alpha-subunits (GLRA1, GLRA2, GLRA3, GLRA4) and one beta-subunit (GLRB) of GlyR have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glycine receptor; glycine receptor alpha 2 subunit; Glycine receptor subunit alpha-2; glycine receptor, alpha 2; glycine receptor, alpha-2 polypeptide
Gene Aliases: GLR; GLRA2
UniProt ID: (Human) P23416, (Mouse) Q7TNC8
Entrez Gene ID: (Human) 2742, (Mouse) 237213
neuropeptide signaling pathway
synapse assembly
spinal cord development
ion transmembrane transport
synaptic transmission, glycinergic
cellular response to amino acid stimulus
cellular response to zinc ion
cellular response to ethanol
chloride transmembrane transport
transport
ion transport
chloride transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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