Immunogen sequence: IRLRRRQRRQ RLEEDIIQES RFYFRGYGLG HCLQARDGGP MEGSGIYSPQ PPAPLLREGE TTRKLYVD
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 81%.
Glra4 is a member of glycine receptors (GlyR), a cys-loop family of ligand-gated ion channels responsible for mediating the inhibitory effects of glycine. GlyR are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine and channel opening is also triggered by taurine and beta-alanine. Glra4 plays a role in the down-regulation of neuronal excitability, and contributes to the generation of inhibitory postsynaptic currents. The Glra4 gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. Glra4 protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for the Glra4 gene. Diseases associated with GLRA4 include Pelizaeus-Merzbacher Disease.
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