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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500 | - |
Immunocytochemistry (ICC/IF) |
1:50 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Peptide (C)KEDVKSGLKGSQPMS, corresponding to amino acid residues 28-42 of mouse Glycine Receptor alpha4 |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Concentration |
0.58 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 1% BSA |
Contains |
0.05% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2735846 |
Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt.
Reconstitute using 50 uL deionized water.
Glra4 is a member of glycine receptors (GlyR), a cys-loop family of ligand-gated ion channels responsible for mediating the inhibitory effects of glycine. GlyR are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine and channel opening is also triggered by taurine and beta-alanine. Glra4 plays a role in the down-regulation of neuronal excitability, and contributes to the generation of inhibitory postsynaptic currents. The Glra4 gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. Glra4 protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for the Glra4 gene. Diseases associated with GLRA4 include Pelizaeus-Merzbacher Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Glycine receptor subunit alpha-4; glycine receptor, alpha 4 subunit
Gene Aliases: Glra4; RGD1564103
UniProt ID: (Mouse) Q61603
Entrez Gene ID: (Human) 441509, (Mouse) 14657, (Rat) 367912
Molecular Function:
ligand-gated ion channel
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