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Invitrogen
GLRB Polyclonal Antibody
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Product Details
PA5-62593
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GLRB. Recombinant protein control fragment (Product #RP-91139).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MLNNPKRVEA EKARIAKAEQ ADGKGGNVAK KNTVNGTGTP VHISTLQVGE TRCKKVCTSK SDLRSNDFSI VGSLPRDFEL SNYDCYGKPI EVNNGLGKSQ AKNNKKPPPA KPVIPTAAK
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
Target Information
In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutryic acid, serotonin and acetylcholine comprise an evolutionally conserved superfamily of ligand-gated ion channels. The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins, alpha1 through alpha4 and beta, and an associated peripheral membrane protein, which combine to form a chloride-selective ion channel. In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca2+ in the brainstem and midbrain indicate an important role for Ca2+ in modulation of glycinergic synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glycine receptor; Glycine receptor 58 kDa subunit; Glycine receptor subunit beta; glycine receptor, beta subunit; GlyR beta; ligand gated ion channel subunit; unnamed protein product
Gene Aliases: GLRB; HKPX2
UniProt ID: (Human) P48167
Entrez Gene ID: (Human) 2743
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
excitatory extracellular ligand-gated ion channel activity
chloride channel activity
protein binding
glycine binding
extracellular-glycine-gated ion channel activity
extracellular-glycine-gated chloride channel activity
macromolecular complex binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
startle response
ion transport
chloride transport
neuropeptide signaling pathway
chemical synaptic transmission
acrosome reaction
nervous system development
visual perception
adult walking behavior
ion transmembrane transport
regulation of membrane potential
neuromuscular process
synaptic transmission, glycinergic
righting reflex
regulation of postsynaptic membrane potential
excitatory postsynaptic potential
gamma-aminobutyric acid receptor clustering
chloride transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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