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Invitrogen
GLRX Polyclonal Antibody
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FIGURE: 1 / 1
GLRX Antibody (PA5-47451) in WB
Western blot analysis of GLRX in NIH-3T3 mouse embryonic fibroblast cell line and C2C12 mouse myoblast cell line. Samples were incubated in GLRX polyclonal antibody (Product # PA5-47451) using a dilution of 0.5 µg/mL followed by a HRP‚conjugated Anti-Goat IgG secondary antibody. A specific band was detected for Glutaredoxin 1 at approximately 12 kDa (as indicated).
Product Details
PA5-47451
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse Glutaredoxin 1 Met1-Leu107
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous human and mouse Glutaradoxin in Western blots.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs form part of the glutaredoxin system, comprising NADPH, GSH and glutathione reductase, which transfers electrons from NADPH to glutaredoxins via GSH. First recovered in E.coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxidoreductase via two redox-active cysteine residues. The active sequence (Cys-Pro-Tyr-Cys) is conserved in a variety of species. The 12-kDa dithiol protein has a role in reduction of mixed disulfides in cells exposed to oxidative stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glutaredoxin (thioltransferase); glutaredoxin 1; glutaredoxin 1 (thioltransferase); Glutaredoxin-1; Glutaredoxin1; Grx 1; MGC117; MGC117407; Thioltransferase 1; Thioltransferase-1; Thioltransferase1; TTase 1; TTase-1; TTase1
Gene Aliases: C86710; D13Wsu156e; Glrx; Glrx1; Grx; Grx1; TTase
UniProt ID: (Mouse) Q9QUH0
Entrez Gene ID: (Mouse) 93692
transport
positive regulation of insulin secretion
cell redox homeostasis
positive regulation of membrane potential
positive regulation of exocytosis
oxidation-reduction process
positive regulation of cell adhesion molecule production
cellular response to estradiol stimulus
positive regulation of NIK/NF-kappaB signaling
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
positive regulation of sodium ion transmembrane transporter activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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