Immunogen sequence: MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ; Positive Samples: SW480, NCI-H460; Cellular Location: Cytoplasm
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer and apos;s disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.
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Protein Aliases: glutaredoxin (thioltransferase); glutaredoxin 1 (thioltransferase); Glutaredoxin-1; thioltransferase; Thioltransferase-1; TTase-1
Gene Aliases: C86710; D13Wsu156e; GLRX; Glrx1; GRX; GRX1; TTase
Molecular Function: oxidoreductase