This antibody is predicted to react with human based on sequence homology.
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.
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Protein Aliases: EAAT2 variant mEAAT2/5UT5; EAAT2, GLT-1, excitatory amino acid transporter 2; Excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; glial high affinity glutamate transporter; GLT-1; GLUT-R; glutamate transporter 1c; glutamate/aspartate transporter II; high affinity glucose transporter; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2; solute carrier family 1, member 2
Gene Aliases: 1700091C19Rik; 2900019G14Rik; AI159670; Eaat2; Glt; GLT-1; GLT1; MGLT1; Slc1a2