Proteintech

GLUT2 Polyclonal Antibody

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GLUT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human small intestine tissue slide using 20436-1-AP ( GLUT2 antibody at dilution of 1:500 (under 40x lens).

GLUT2 Antibody in Western Blot (WB) — Mouse small intestine tissue were subjected to SDS PAGE followed by western blot with 20436-1-AP (GLUT2 antibody at dilution of 1:600 incubated at room temperature for 1.5 hours.

GLUT2 Antibody in Immunoprecipitation (IP) — IP result of anti-GLUT2 (IP:20436-1-AP, 4ug; Detection:20436-1-AP 1:1000) with mouse kidney tissue lysate 4000ug.

Product Details

20436-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:200-1:1,000	View 4 publications 4 publications
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:1,000	-
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	GLUT2 Fusion Protein Ag14204 (69-128 aa encoded by BC060041) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.22 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

This antibody detected 60-70 kDa fully glycosylated, matured GLUT2 and a nonglycosylated form of GLUT2 around 38-45 kDa.

Immunogen sequence: SPRYLYIKL DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY R (69-128 aa encoded by BC060041)

Target Information

Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in the gene that encode this protein cause Fanconi-Bickel syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways.

Molecular metabolism

Smith K,Karimian Azari E,LaMoia TE,Hussain T,Vargova V,Karolyi K,Veldhuis PP,Arnoletti JP,de la Fuente SG,Pratley RE,Osborne TF,Kyriazis GA

Thu Nov 01 00:00:00 EDT 2018

Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction.

ACS nano

Sun Y,Shi H,Yin S,Ji C,Zhang X,Zhang B,Wu P,Shi Y,Mao F,Yan Y,Xu W,Qian H

Tue Aug 28 00:00:00 EDT 2018

Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction.

ACS nano

Sun Y,Shi H,Yin S,Ji C,Zhang X,Zhang B,Wu P,Shi Y,Mao F,Yan Y,Xu W,Qian H

Tue Aug 28 00:00:00 EDT 2018

Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.

Journal of molecular endocrinology

Shen CT,Wei WJ,Qiu ZL,Song HJ,Zhang XY,Sun ZK,Luo QY

Sun Jan 01 00:00:00 EST 2017

TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.

Scientific reports

Dong F,Ling Q,Ye D,Zhang Z,Shu J,Chen G,Fei Y,Li C

Mon Apr 25 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: glucose transporter 2; Glucose transporter type 2, liver; GLUT-2; liver-type glucose transporter; solute carrier family 2 (facilitated glucose transporter), member 2; Solute carrier family 2, facilitated glucose transporter member 2

Gene Aliases: AI266973; Glut-2; GLUT2; GTT2; SLC2A2

UniProt ID: (Human) P11168, (Mouse) P14246

Entrez Gene ID: (Human) 6514, (Mouse) 20526, (Rat) 25351

Function(s)