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GLUT2 Polyclonal Antibody

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Antibody Testing Data (9)

GLUT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

GLUT2 Antibody (20436-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human small intestine tissue slide using 20436-1-AP ( GLUT2 antibody at dilution of 1:500 (under 40x lens).

Product Image Gallery

GLUT2 Antibody in Western Blot (WB) — Mouse small intestine tissue were subjected to SDS PAGE followed by western blot with 20436-1-AP (GLUT2 antibody at dilution of 1:600 incubated at room temperature for 1.5 hours.

GLUT2 Antibody in Immunoprecipitation (IP) — IP result of anti-GLUT2 (IP:20436-1-AP, 4ug; Detection:20436-1-AP 1:1000) with mouse kidney tissue lysate 4000ug.

Product Details

20436-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 38 publications 38 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:1,000

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GLUT2 Fusion Protein Ag14204 (69-128 aa encoded by BC060041)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

This antibody detected 60-70 kDa fully glycosylated, matured GLUT2 and a nonglycosylated form of GLUT2 around 38-45 kDa.

Immunogen sequence: SPRYLYIKL DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY R (69-128 aa encoded by BC060041)

Target Information

Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in the gene that encode this protein cause Fanconi-Bickel syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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European journal of nutrition

Wu X,Cui L,Wang H,Xu J,Zhong Z,Jia X,Wang J,Zhang H,Shi Y,Tang Y,Yang Q,Liang Q,Zhang Y,Li J,Jiang X

Wed Feb 01 00:00:00 EST 2023

A novel purgative mechanism of multiflorin A involves changing intestinal glucose absorption and permeability.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhao Z,Zuo X,Han C,Zhang Y,Zhao J,Wang Y,Zhang S,Li W

Thu Jun 01 00:00:00 EDT 2023

Effect of duodenal-jejunal bypass on diabetes in the early postoperative period.

Scientific reports

Okikawa S,Kashihara H,Shimada M,Yoshikawa K,Tokunaga T,Nishi M,Takasu C,Wada Y,Yoshimoto T

Wed Feb 01 00:00:00 EST 2023

Onchidium struma polysaccharides exhibit hypoglycemic activity and modulate the gut microbiota in mice with type 2 diabetes mellitus.

Food & function

Zhao Y,Song P,Yin S,Fan T,Li F,Ge X,Liu T,Xu W,Xu S,Chen L

Tue Feb 21 00:00:00 EST 2023

The effect of PINK1/Parkin pathway on glucose homeostasis imbalance induced by tacrolimus in mouse livers.

Heliyon

Li Z,Xiang J,Mei S,Wu Y,Xu Y

Sat Apr 01 00:00:00 EDT 2023

Polymethoxyflavone-Enriched Fraction from Ougan (Citrus reticulata cv. Suavissima) Attenuated Diabetes and Modulated Gut Microbiota in Diabetic KK-A^y Mice.

Journal of agricultural and food chemistry

Chen J,Liu Y,Wang H,Liang X,Ji S,Wang Y,Li X,Sun C

Wed May 10 00:00:00 EDT 2023

Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis.

Metabolism: clinical and experimental

Chun HJ,Kim ER,Lee M,Choi DH,Kim SH,Shin E,Kim JH,Cho JW,Han DH,Cha BS,Lee YH

Tue Aug 01 00:00:00 EDT 2023

Female athlete triad affects rat intestinal morphology and sucrase-isomaltase expression.

The British journal of nutrition

Aoki K,Ebina K,Shingu H,Kioka K,Sugasawa T,Kawakami Y,Takekoshi K,Omi N

Fri Jul 14 00:00:00 EDT 2023

Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.

Annals of hepatology

Cook JJ,Wei M,Segovia B,Cosio-Lima L,Simpson J,Taylor S,Koh Y,Kim S,Lee Y

Thu Jul 07 00:00:00 EDT 2022

Role of Proximal Intestinal Glucose Sensing and Metabolism in the Blood Glucose Control in Type 2 Diabetic Rats After Duodenal Jejunal Bypass Surgery.

Obesity surgery

Jiang B,Wang H,Li N,Yan Q,Wang W,Wang Y,Xue H,Ma S,Li X,Diao W,Pan R,Gao Z,Qu MH

Fri Apr 01 00:00:00 EDT 2022

Partial freezing of rat livers extends preservation time by 5-fold.

Nature communications

Tessier SN,de Vries RJ,Pendexter CA,Cronin SEJ,Ozer S,Hafiz EOA,Raigani S,Oliveira-Costa JP,Wilks BT,Lopera Higuita M,van Gulik TM,Usta OB,Stott SL,Yeh H,Yarmush ML,Uygun K,Toner M

Fri Jul 15 00:00:00 EDT 2022

Murine remote ischemic preconditioning upregulates preferentially hepatic glucose transporter-4 via its plasma membrane translocation, leading to accumulating glycogen in the liver.

Life sciences

Kurabayashi A,Furihata K,Iwashita W,Tanaka C,Fukuhara H,Inoue K,Furihata M,Kakinuma Y

Tue Feb 01 00:00:00 EST 2022

Murine remote ischemic preconditioning upregulates preferentially hepatic glucose transporter-4 via its plasma membrane translocation, leading to accumulating glycogen in the liver.

Life sciences

Kurabayashi A,Furihata K,Iwashita W,Tanaka C,Fukuhara H,Inoue K,Furihata M,Kakinuma Y

Tue Feb 01 00:00:00 EST 2022

Effects of apolipoprotein E on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae.

Life sciences

Liu M,Chen MY,An L,Ma SQ,Mei J,Huang WH,Zhang W

Tue Nov 01 00:00:00 EDT 2022

Effects of apolipoprotein E on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae.

Life sciences

Liu M,Chen MY,An L,Ma SQ,Mei J,Huang WH,Zhang W

Tue Nov 01 00:00:00 EDT 2022

Comparative study on the gastrointestinal- and immune- regulation functions of Hedysari Radix Paeparata Cum Melle and Astragali Radix Praeparata cum Melle in rats with spleen-qi deficiency, based on fuzzy matter-element analysis.

Pharmaceutical biology

Zhang Y,Niu J,Zhang S,Si X,Bian TT,Wu H,Li D,Sun Y,Jia J,Xin E,Yan X,Li Y

Thu Dec 01 00:00:00 EST 2022

Melatonin protects against nonylphenol caused pancreatic β-cells damage through MDM2-P53-P21 axis.

Toxicology research

Tao S,Yang Y,Fan Y,Chu K,Sun J,Wu Q,Wang A,Wan J,Tian H

Wed Jun 01 00:00:00 EDT 2022

Singapore Grouper Iridovirus Induces Glucose Metabolism in Infected Cells by Activation of Mammalian Target of Rapamycin Signaling.

Frontiers in microbiology

Guo X,Zheng Q,Pan Z,Huang Y,Huang X,Qin Q

Fri May 06 00:00:00 EDT 2022

Aqueous Extract of Guava (Psidium guajava L.) Leaf Ameliorates Hyperglycemia by Promoting Hepatic Glycogen Synthesis and Modulating Gut Microbiota.

Frontiers in pharmacology

Chu S,Zhang F,Wang H,Xie L,Chen Z,Zeng W,Zhou Z,Hu F

Sat Jul 16 00:00:00 EDT 2022

Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.

Cells

Wang Y,Wang Y,Li F,Zou J,Li X,Xu M,Yu D,Ma Y,Huang W,Sun X,Zhang Y

Tue Mar 22 00:00:00 EDT 2022

Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance.

The Journal of endocrinology

Qin W,Zhang T,Ge M,Zhou H,Xu Y,Mu R,Huang C,Liu D,Huang B,Wang Q,Kong Q,Kong Q,Li F,Xiong W

Thu Sep 01 00:00:00 EDT 2022

The glucotoxicity protecting effect of honokiol in human hepatocytes via directly activating AMPK.

Frontiers in nutrition

Liu H,Luo W,Liu J,Kang X,Yan J,Zhang T,Yang L,Shen L,Liu D

Tue Dec 06 00:00:00 EST 2022

The glucotoxicity protecting effect of honokiol in human hepatocytes via directly activating AMPK.

Frontiers in nutrition

Liu H,Luo W,Liu J,Kang X,Yan J,Zhang T,Yang L,Shen L,Liu D

Tue Dec 06 00:00:00 EST 2022

Fat mass and obesity-associated gene (FTO) hypermethylation induced by decabromodiphenyl ethane causing cardiac dysfunction via glucolipid metabolism disorder.

Ecotoxicology and environmental safety

Gao L,Zhang Y,Liu J,Li X,Sang Y,Zhou G,Xue J,Jing L,Shi Z,Wei J,Lu X,Zhou X

Wed Jun 01 00:00:00 EDT 2022

Understanding the Role of GLUT2 in Dysglycemia Associated with Fanconi-Bickel Syndrome.

Biomedicines

Sharari S,Kabeer B,Mohammed I,Haris B,Pavlovski I,Hawari I,Bhat AA,Toufiq M,Tomei S,Mathew R,Syed N,Nisar S,Maacha S,Grivel JC,Chaussabel D,Ericsson J,Hussain K

Mon Aug 29 00:00:00 EDT 2022

Sirtuin 6 affects glucose reabsorption and gluconeogenesis in type 1 diabetes via FoxO1.

Molecular and cellular endocrinology

Bian C,Zhang R,Wang Y,Li J,Song Y,Guo D,Gao J,Ren H

Sun May 01 00:00:00 EDT 2022

Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.

Food & function

Liu Y,Huang H,Xu Z,Xue Y,Zhang D,Zhang Y,Li W,Li X

Mon Mar 07 00:00:00 EST 2022

ERα down-regulates carbohydrate responsive element binding protein and decreases aerobic glycolysis in liver cancer cells.

Journal of cellular and molecular medicine

Lu Y,Tian N,Hu L,Meng J,Feng M,Zhu Y,Zhang P,Li M,Liu Q,Tong L,Tong X,Li Y,Wu L

Thu Apr 01 00:00:00 EDT 2021

Decabromodiphenyl ether induces male reproductive toxicity by activating mitochondrial apoptotic pathway through glycolipid metabolism dysbiosis.

Chemosphere

Zhang Y,Li X,Jing L,Zhou G,Sang Y,Gao L,Jiang S,Shi Z,Ge W,Sun Z,Zhou X

Wed Dec 01 00:00:00 EST 2021

Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice.

Nutrients

Aoki K,Suzuki T,Hui F,Nakano T,Yanazawa K,Yonamine M,Fujita S,Sugasawa T,Yoshida Y,Omi N,Kawakami Y,Takekoshi K

Thu May 20 00:00:00 EDT 2021

Proper mTORC1 Activity Is Required for Glucose Sensing and Early Adaptation in Human Pancreatic β Cells.

The Journal of clinical endocrinology and metabolism

Ni Q,Song J,Wang Y,Sun J,Xie J,Zhang J,Ning G,Wang W,Wang Q

Sat Jan 23 00:00:00 EST 2021

Downregulation of GLUT3 impairs STYK1/NOK-mediated metabolic reprogramming and proliferation in NIH-3T3 cells.

Oncology letters

Shi W,Fu Y,Wang Y

Thu Jul 01 00:00:00 EDT 2021

Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas.

Cellular and molecular gastroenterology and hepatology

Wang H,Lu J,Mandel JA,Zhang W,Schwalbe M,Gorka J,Liu Y,Marburger B,Wang J,Ranganathan S,Prochownik EV

Mon Jan 24 00:00:00 EST 2022

Rheb1 promotes glucose-stimulated insulin secretion in human and mouse β-cells by upregulating GLUT expression.

Metabolism: clinical and experimental

Yang Y,Cai Z,Pan Z,Liu F,Li D,Ji Y,Zhong J,Luo H,Hu S,Song L,Yu S,Li T,Li J,Ma X,Zhang W,Zhou Z,Liu F,Zhang J

Fri Oct 01 00:00:00 EDT 2021

Expression and Function of Organic Cation Transporter 2 in Pancreas.

Frontiers in cell and developmental biology

Schorn S,Dicke AK,Neugebauer U,Schröter R,Friedrich M,Reuter S,Ciarimboli G

Tue Jun 15 00:00:00 EDT 2021

Celastrol inhibits intestinal lipid absorption by reprofiling the gut microbiota to attenuate high-fat diet-induced obesity.

iScience

Hua H,Zhang Y,Zhao F,Chen K,Wu T,Liu Q,Huang S,Zhang A,Jia Z

Fri Feb 19 00:00:00 EST 2021

Up-Regulation of Glycogen Synthesis and Degradation Enzyme Level Maintained Myocardial Glycogen in Huddling Brandt's Voles Under Cool Environments.

Frontiers in physiology

Xu JH,Wang Z,Mou JJ,Wang CL,Huang WM,Xue HL,Wu M,Chen L,Xu LX

Tue Apr 13 00:00:00 EDT 2021

Effects of canagliflozin on growth and metabolic reprograming in hepatocellular carcinoma cells: Multi-omics analysis of metabolomics and absolute quantification proteomics (iMPAQT).

PloS one

Nakano D,Kawaguchi T,Iwamoto H,Hayakawa M,Koga H,Torimura T

Thu Jul 23 00:00:00 EDT 2020

Effect of hepatic sympathetic nerve removal on energy metabolism in an animal model of cognitive impairment and its relationship to Glut2 expression.

Open life sciences

Wei R,Zhuge X,Yue P,Liu M,Zhu L,Liu J,Xia C

Tue Apr 06 00:00:00 EDT 2021

O⁶-methylguanine DNA methyltransferase and glucose transporter 2 in foregut and hindgut gastrointestinal neuroendocrine neoplasms.

BMC cancer

Watanabe H,Yamazaki Y,Fujishima F,Izumi K,Imamura M,Hijioka S,Toriyama K,Yatabe Y,Kudo A,Motoi F,Unno M,Sasano H

Mon Dec 07 00:00:00 EST 2020

CYP3A4 and microRNA-122 are involved in the apoptosis of HepG2 cells induced by ILs 1-decyl-3-methylimidazolium bromide.

Journal of biochemical and molecular toxicology

Li AL,Gao SS,Guo ML,Jing CQ

Wed Jan 01 00:00:00 EST 2020

L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.

Food & function

Xu W,Lin L,Liu A,Zhang T,Zhang S,Li Y,Chen J,Gong Z,Liu Z,Xiao W

Wed Sep 23 00:00:00 EDT 2020

Pea-derived peptides, VLP, LLP, VA, and LL, improve insulin resistance in HepG2 cells via activating IRS-1/PI3K/AKT and blocking ROS-mediated p38MAPK signaling.

Journal of food biochemistry

Zhu Y,Zhang H,Wei Y,Cai M,Gu R,Wang Y,Ma Y,Chen L

Sun Nov 01 00:00:00 EDT 2020

Paraneoplastic β Cell Dedifferentiation in Nondiabetic Patients with Pancreatic Cancer.

The Journal of clinical endocrinology and metabolism

Wang Y,Ni Q,Sun J,Xu M,Xie J,Zhang J,Fang Y,Ning G,Wang Q

Wed Apr 01 00:00:00 EDT 2020

The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.

Autophagy

Huang X,Gan G,Wang X,Xu T,Xie W

Mon Jul 01 00:00:00 EDT 2019

Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria.

Journal of food science

Han X,Zhang Y,Guo J,You Y,Zhan J,Huang W

Sun Dec 01 00:00:00 EST 2019

High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells.

Cell metabolism

Hu CM,Tien SC,Hsieh PK,Jeng YM,Chang MC,Chang YT,Chen YJ,Chen YJ,Lee EYP,Lee WH

Tue Jun 04 00:00:00 EDT 2019

Effect of Konjac Mannan Oligosaccharides on Glucose Homeostasis via the Improvement of Insulin and Leptin Resistance In Vitro and In Vivo.

Nutrients

Zhu D,Yan Q,Li Y,Liu J,Liu H,Jiang Z

Wed Jul 24 00:00:00 EDT 2019

Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction.

ACS nano

Sun Y,Shi H,Yin S,Ji C,Zhang X,Zhang B,Wu P,Shi Y,Mao F,Yan Y,Xu W,Qian H

Tue Aug 28 00:00:00 EDT 2018

Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction.

ACS nano

Sun Y,Shi H,Yin S,Ji C,Zhang X,Zhang B,Wu P,Shi Y,Mao F,Yan Y,Xu W,Qian H

Tue Aug 28 00:00:00 EDT 2018

Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction.

ACS nano

Sun Y,Shi H,Yin S,Ji C,Zhang X,Zhang B,Wu P,Shi Y,Mao F,Yan Y,Xu W,Qian H

Tue Aug 28 00:00:00 EDT 2018

Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction.

ACS nano

Sun Y,Shi H,Yin S,Ji C,Zhang X,Zhang B,Wu P,Shi Y,Mao F,Yan Y,Xu W,Qian H

Tue Aug 28 00:00:00 EDT 2018

T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways.

Molecular metabolism

Smith K,Karimian Azari E,LaMoia TE,Hussain T,Vargova V,Karolyi K,Veldhuis PP,Arnoletti JP,de la Fuente SG,Pratley RE,Osborne TF,Kyriazis GA

Thu Nov 01 00:00:00 EDT 2018

T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways.

Molecular metabolism

Smith K,Karimian Azari E,LaMoia TE,Hussain T,Vargova V,Karolyi K,Veldhuis PP,Arnoletti JP,de la Fuente SG,Pratley RE,Osborne TF,Kyriazis GA

Thu Nov 01 00:00:00 EDT 2018

Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.

Journal of molecular endocrinology

Shen CT,Wei WJ,Qiu ZL,Song HJ,Zhang XY,Sun ZK,Luo QY

Sun Jan 01 00:00:00 EST 2017

Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.

Journal of molecular endocrinology

Shen CT,Wei WJ,Qiu ZL,Song HJ,Zhang XY,Sun ZK,Luo QY

Sun Jan 01 00:00:00 EST 2017

TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.

Scientific reports

Dong F,Ling Q,Ye D,Zhang Z,Shu J,Chen G,Fei Y,Li C

Mon Apr 25 00:00:00 EDT 2016

TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.

Scientific reports

Dong F,Ling Q,Ye D,Zhang Z,Shu J,Chen G,Fei Y,Li C

Mon Apr 25 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: glucose transporter 2; Glucose transporter type 2, liver; GLUT-2; liver-type glucose transporter; solute carrier family 2 (facilitated glucose transporter), member 2; Solute carrier family 2, facilitated glucose transporter member 2

Gene Aliases: AI266973; Glut-2; GLUT2; GTT2; SLC2A2

UniProt ID: (Human) P11168, (Mouse) P14246

Entrez Gene ID: (Human) 6514, (Mouse) 20526, (Rat) 25351

Function(s)

transport carbohydrate transport carbohydrate utilization glucose transport proton transport carbohydrate transmembrane transport hexose transmembrane transport glucose import transmembrane transport dehydroascorbic acid transport cation transmembrane transport carbohydrate metabolic process hexose transport response to glucose fructose transport response to peptide hormone regulation of insulin secretion glucose transmembrane transport

Process(es)

insulin receptor binding glucose transmembrane transporter activity hexose transmembrane transporter activity dehydroascorbic acid transporter activity D-glucose transmembrane transporter activity transporter activity sugar:proton symporter activity transmembrane transporter activity substrate-specific transmembrane transporter activity

GLUT2 Polyclonal Antibody

GLUT2 Antibody (20436-1-AP) in IHC (P)

Product Details

20436-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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