This antibody is predicted to react with rat based on 100% sequence homology.
Glucose Transporter 4 (GLUT4/SLC2A4) is a member of a family of proteins that facilitate glucose transport. In response to insulin GLUT4 translocates from low density microsomes to the plasma membrane. Activation of phosphatidylinositol-3-OH kinase is required for this trafficking event but is not sufficient. Insulin resistant subjects with and without diabetes show abnormal accumulation of GLUT4 in a dense membrane compartment in muscle and adipocytes from which insulin is unable to recruit GLUT4 to the cell surface.
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Protein Aliases: facilitated glucose transporter member 4; Glucose transporter 4 insuline-responsive; Glucose transporter 4, insuline-responsive; glucose transporter type 4; Glucose transporter type 4, insulin-responsive; GLUT-4; GLUT4; GT2; insulin responsive glucose transporter; insulin-responsive; insulin-responsive glucose transporter type 4; solute carrier family 2; solute carrier family 2 member 4; solute carrier family 2 (facilitated glucose transporter), member 4; solute carrier family 2 , member 4; Solute carrier family 2, facilitated glucose transporter member 4
Gene Aliases: Glut-4; GLUT4; SLC2A4