This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human Glut4/SLC2A4.
The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 (Glucose transporter type 4, insulin-responsive) glucose transporter from intracellular storage sites to the cell surface. Insulin stimulates glucose transport by promoting translocation of GLUT4 proteins from the perinuclear compartment to the cell surface. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Glucose transporter type 4; Glucose transporter type 4, insulin-responsive; GLUT-4; insulin-responsive; insulin-responsive glucose transporter type 4; solute carrier family 2 (facilitated glucose transporter), member 4; Solute carrier family 2, facilitated glucose transporter member 4
Gene Aliases: GLUT4; SLC2A4
UniProt ID: (Human) P14672
Entrez Gene ID: (Human) 6517