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Proteintech
GM2A Polyclonal Antibody
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Product Details
10864-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GM2A Fusion Protein Ag1295 (1-193 aa encoded by BC009273)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MQSLMQAPL LIALGLLLAA PAQAHLKKPS QLSSFSWDNC DEGKDPAVIR SLTLEPDPIV VPGNVTLSVV GSTSVPLSSP LKVDLVLEKE VAGLWIKIPC TDYIGSCTFE HFCDVLDMLI PTGEPCPEPL RTYGLPCHCP FKEGTYSLPK SEFVVPDLEL PSWLTTGNYR IESVLSSSGK RLGCIKIAAS LKGI (1-193 aa encoded by BC009273)
Target Information
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cerebroside sulfate activator protein; Ganglioside GM2 activator; GM2 ganglioside activator; GM2 ganglioside activator protein; GM2-activator protein; GM2-AP; SAP-3; shingolipid activator protein 3; Sphingolipid activator protein 3; unnamed protein product
Gene Aliases: AA408702; AW215435; GM2-AP; GM2A; GM2AP; SAP-3
UniProt ID: (Human) P17900, (Mouse) Q60648
Entrez Gene ID: (Human) 2760, (Mouse) 14667, (Rat) 282838
ganglioside metabolic process
lipid metabolic process
sphingolipid metabolic process
ganglioside catabolic process
lipid transport
learning or memory
oligosaccharide catabolic process
lipid storage
glycosphingolipid catabolic process
neurological system process
neuromuscular process controlling balance
positive regulation of catalytic activity
positive regulation of hydrolase activity
membrane fusion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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