Proteintech

GMPR 1/2 Polyclonal Antibody

6 References

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (4)

GMPR 1/2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

GMPR 1/2 Antibody (15683-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 15683-1-AP (GMPR 1/2 antibody) at dilution of 1:100 (under 40x lens).

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Product Details

15683-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GMPR 1/2 Fusion Protein Ag8185 (1-345 aa encoded by BC008281)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize both GMPR1 and GMPR2 due to the high homology.

Immunogen sequence: MPRIDADLK LDFKDVLLRP KRSSLKSRAE VDLERTFTFR NSKQTYSGIP IIVANMDTVG TFEMAAVMSQ HSMFTAIHKH YSLDDWKLFA TNHPECLQNV AVSSGSGQND LEKMTSILEA VPQVKFICLD VANGYSEHFV EFVKLVRAKF PEHTIMAGNV VTGEMVEELI LSGADIIKVG VGPGSVCTTR TKTGVGYPQL SAVIECADSA HGLKGHIISD GGCTCPGDVA KAFGAGADFV MLGGMFSGHT ECAGEVIERN GRKLKLFYGM SSDTAMNKHA GGVAEYRASE GKTVEVPYKG DVENTILDIL GGLRSTCTYV GAAKLKELSR RATFIRVTQQ HNTVFS (1-345 aa encoded by B C008281)

Target Information

This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.

Cell reports

Sayles NM,Southwell N,McAvoy K,Kim K,Pesini A,Anderson CJ,Quinzii C,Cloonan S,Kawamata H,Manfredi G

Tue Mar 08 00:00:00 EST 2022

Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4.

Cell chemical biology

Wolff DW,Deng Z,Bianchi-Smiraglia A,Foley CE,Han Z,Wang X,Shen S,Rosenberg MM,Moparthy S,Yun DH,Chen J,Baker BK,Roll MV,Magiera AJ,Li J,Hurley E,Feltri ML,Cox AO,Lee J,Furdui CM,Liu L,Bshara W,LaConte LEW,Kandel ES,Pasquale EB,Qu J,Hedstrom L,Nikiforov MA

Thu Jun 16 00:00:00 EDT 2022

Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4.

Cell chemical biology

Thu Jun 16 00:00:00 EDT 2022

Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4.

Cell chemical biology

Thu Jun 16 00:00:00 EDT 2022

Reducing Fatty Acid Oxidation Improves Cancer-free Survival in a Mouse Model of Li-Fraumeni Syndrome.

Cancer prevention research (Philadelphia, Pa.)

Wang PY,Ma J,Li J,Starost MF,Wolfgang MJ,Singh K,Pirooznia M,Kang JG,Hwang PM

Fri Jan 01 00:00:00 EST 2021

Regulation of local GTP availability controls RAC1 activity and cell invasion.

Nature communications

Bianchi-Smiraglia A,Wolff DW,Marston DJ,Deng Z,Han Z,Moparthy S,Wombacher RM,Mussell AL,Shen S,Chen J,Yun DH,O'Brien Cox A,Furdui CM,Hurley E,Feltri ML,Qu J,Hollis T,Kengne JBN,Fongang B,Sousa RJ,Kandel ME,Kandel ES,Hahn KM,Nikiforov MA

Tue Oct 19 00:00:00 EDT 2021

Bioinformatics

Protein Aliases: GMP reductase 1; GMP reductase 2; GMPR 1; GMPR 2; guanine monophosphate reductase; Guanosine 5'-monophosphate oxidoreductase 1; Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 1; Guanosine monophosphate reductase 2; guanosine monophosphate reductase isolog

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Gene Aliases: 1810008P16Rik; 2310004P21Rik; 5730544D12Rik; AA959850; AV028449; GMPR; GMPR 1; GMPR 2; GMPR1; GMPR2

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UniProt ID: (Human) P36959, (Human) Q9P2T1, (Mouse) Q9DCZ1, (Rat) Q9Z244, (Mouse) Q99L27

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Entrez Gene ID: (Human) 2766, (Human) 51292, (Mouse) 66355, (Rat) 117533, (Mouse) 105446, (Rat) 192357

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Function(s)

GMP reductase activity metal ion binding catalytic activity oxidoreductase activity reductase

Process(es)

purine nucleobase metabolic process purine nucleotide metabolic process response to cold purine-containing compound salvage oxidation-reduction process GMP metabolic process nucleotide metabolic process monocyte differentiation GMP catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GMPR 1/2 Polyclonal Antibody

GMPR 1/2 Antibody (15683-1-AP) in IHC (P)

Product Details

15683-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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