FIGURE: 1 / 1
Immunogen sequence: AGGDLKDGHHH YEGAVVILDA GAQYGKVIDR RVRELFVQSE IFPLETPAFA IKEQGFRAII ISGGPNSVYA EDAPWFDPAI FTIGKPVLGI CYGMQMMNKV FGGTVHKKSV REDGVFNISV DNTCSLFRGL QKEEVVLLT
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 98%.
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Glutamine amidotransferase; GMP synthase; GMP synthase [glutamine-hydrolyzing]; GMP synthetase; guanine monophosphate synthetase; guanosine 5'-monophosphate synthase; MLL/GMPS fusion protein; testicular tissue protein Li 82
Gene Aliases: GMPS
UniProt ID: (Human) P49915
Entrez Gene ID: (Human) 8833
Molecular Function: ligase