This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Zebrafish: 86%
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).
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Protein Aliases: G alpha-11; G-protein subunit alpha-11; G-protein subunit GL2 alpha; Gq class; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); guanine nucleotide regulatory protein G alpha 11; guanine nucleotide-binding protein alpha 11 subunit; Guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11
Gene Aliases: BOS_7750; Dsk7; E430025L19; FBH; FBH2; FHH2; G alpha-11; GA11; GNA-11; GNA11; HHC2; HYPOC2