The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far.
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Protein Aliases: Adenylate cyclase-inhibiting G alpha protein; BR; CD49B; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); GTP-binding protein (G-alpha-i2); GTP-binding regulatory protein Gi alpha-2 chain; guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein, alpha inhibiting 2; Guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-2 subunit; VLA-2; VLAA2
Gene Aliases: C76432; Galphai2; Gia; GIP; Gnai-2; GNAI2; GNAI2B; H_LUCA15.1; H_LUCA16.1
Molecular Function: heterotrimeric G-protein