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Proteintech
GNAI3 Polyclonal Antibody
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Product Details
11641-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GNAI3 Fusion Protein Ag2229 (1-354 aa encoded by BC025285)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGCTLSAED KAAVERSKMI DRNLREDGEK AAKEVKLLLL GAGESGKSTI VKQMKIIHED GYSEDECKQY KVVVYSNTIQ SIIAIIRAMG RLKIDFGEAA RADDARQLFV LAGSAEEGVM TPELAGVIKR LWRDGGVQAC FSRSREYQLN DSASYYLNDL DRISQSNYIP TQQDVLRTRV KTTGIVETHF TFKDLYFKMF DVGGQRSERK KWIHCFEGVT AIIFCVALSD YDLVLAEDEE MNRMHESMKL FDSICNNKWF TETSIILFLN KKDLFEEKIK RSPLTICYPE YTGSNTYEEA AAYIQCQFED LNRRKDTKEI YTHFTCATDT KNVQFVFDAV TDVIIKNNLK ECGLY (1-354 aa encoded by BC025285)
Target Information
Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i. e. adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alpha, beta and gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their alpha subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of Galpha subunits have been identified; these include Gs, Gi, Gq and Galpha 12/13. The Gi class comprises all the known alpha subunits that are susceptible to pertussis toxin modifications, including Galpha i-1, Galpha i-2, Galpha i-3, Galpha o, Galpha t1, Galpha t2, Galpha z and Galpha gust. Of these, the three Galpha i subtypes function to open atrial potassium channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G protein; G protein alpha subunit; G(i) alpha-3; GTP-binding protein alpha subunit; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; guanine nucleotide binding protein, alpha inhibiting 3; guanine nucleotide-binding protein (G) alpha subunit; guanine nucleotide-binding protein G(i) subunit alpha; Guanine nucleotide-binding protein G(i) subunit alpha-3; guanine nucleotide-binding protein G(k) subunit alpha; guanine nucleotide-binding regulatory protein alpha-inhibitory subunit; heterotrimeric guanine nucleotide-binding protein 1A; unnamed protein product
Gene Aliases: 87U6; AI158965; ARCND1; ARCODS; AW537698; Galphai3; Gnai-3; GNAI3; HG1A
UniProt ID: (Human) P08754, (Mouse) Q9DC51
Entrez Gene ID: (Human) 2773, (Mouse) 14679
nucleotide binding
G-protein coupled receptor binding
GTPase activity
protein binding
GTP binding
guanyl nucleotide binding
GDP binding
G-protein beta/gamma-subunit complex binding
metal ion binding
signal transducer activity
protein domain specific binding
G-protein coupled serotonin receptor binding
GTPase activating protein binding
heterotrimeric G-protein
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
positive regulation of macroautophagy
GTP metabolic process
cell division
vesicle fusion
cell cycle
regulation of heart contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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