FIGURE: 1 / 1
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.
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Protein Aliases: DKFZp686O0962; G alpha o; GNAO 1; Go alpha; GTP-binding protein alpha o; GTP-binding protein alpha-o subunit; guanine nucleotide binding protein, alpha O polypeptide 1; Guanine nucleotide-binding protein G(o) subunit alpha
Gene Aliases: alphaO; AW050213; Galphao; Gna0; Gnao; Gnao1; RATBPGTPC
Molecular Function: heterotrimeric G-protein