Immunogen sequence: SDNENRMEES KALFRTIITY PWFQNS
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).
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Protein Aliases: G-ALPHA-q; GAQ; guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding protein alpha-q; Guanine nucleotide-binding protein G(q) subunit alpha
Gene Aliases: CMC1; G-ALPHA-q; GAQ; GNAQ; SWS
UniProt ID: (Human) P50148
Entrez Gene ID: (Human) 2776