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Invitrogen
GNAS (R201C Mutant) Polyclonal Antibody
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FIGURE: 1 / 1
GNAS (R201C Mutant) Antibody (PA5-119556) in WB
Western blot analysis of GNAS (R201C Mutant) in Non-transfected (-) and transfected (+) 293T whole cell extracts (30 µg). Sample was separated with 10% SDS-PAGE, incubated with polyclonal GNAS (R201C Mutant) antibody (Product # PA5-119556) at a dilution of 1:10000, and followed by HRP-conjugated anti-rabbit IgG.
Product Details
PA5-119556
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide surrounding mutant R201C of mouse GNAS. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.96 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Target Information
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5530400H20Rik; A930027G11Rik; Adenylate cyclase-stimulating G alpha protein; alpha stimulating) complex locus; Alternative gene product encoded by XL-exon; C130027O20Rik; Extra large alphas protein; G protein; G protein subunit alpha S; Galphas; GNAS (guanine nucleotide binding protein; Gnas1; Gnasxl; GNSA1; GPSA; Gs alpha subunit; Gs-alpha; Gsa; GSP; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; guanine nucleotide-binding protein alpha subunit; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Nesp; NESP55; NESP55; large dense core vesicle secretory protein; Nespl; Neuroendocrine secretory protein 55; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; Protein ALEX; SCG6; secretogranin VI; stimulatory G-protein alpha subunit; unnamed protein product; XLalphas
Gene Aliases: 5530400H20Rik; A930027G11Rik; AHO; AIMAH1; C130027O20Rik; C20orf45; Galphas; GNAS; GNAS1; Gnasxl; GPSA; GSA; GSP; MNCb-5546; NESP; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; PITA3; POH; SCG6; SgVI
UniProt ID: (Human) Q5JWF2, (Mouse) Q6R0H7
Entrez Gene ID: (Human) 2778, (Mouse) 14683
nucleotide binding
GTPase activity
obsolete small monomeric GTPase activity
insulin-like growth factor receptor binding
protein binding
GTP binding
adenylate cyclase regulator activity
adenylate cyclase activator activity
hydrolase activity
guanyl nucleotide binding
G-protein beta/gamma-subunit complex binding
beta-2 adrenergic receptor binding
D1 dopamine receptor binding
mu-type opioid receptor binding
ionotropic glutamate receptor binding
metal ion binding
corticotropin-releasing hormone receptor 1 binding
G-protein alpha-subunit binding
signal transducer activity
protein domain specific binding
G-protein beta-subunit binding
alpha-tubulin binding
heterotrimeric G-protein
negative regulation of inflammatory response to antigenic stimulus
renal water homeostasis
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating serotonin receptor signaling pathway
female pregnancy
sensory perception of chemical stimulus
sensory perception of smell
protein secretion
regulation of signal transduction
regulation of skeletal muscle contraction
response to prostaglandin E
negative regulation of multicellular organism growth
intracellular transport
developmental growth
positive regulation of phagocytosis
regulation of insulin secretion
cognition
bone development
hair follicle placode formation
platelet aggregation
response to parathyroid hormone
cellular response to glucagon stimulus
cellular response to prostaglandin E stimulus
cellular response to acidic pH
cellular response to catecholamine stimulus
adenylate cyclase-activating adrenergic receptor signaling pathway
vascular endothelial cell response to laminar fluid shear stress
positive regulation of cold-induced thermogenesis
skeletal system development
tissue homeostasis
positive regulation of protein phosphorylation
endochondral ossification
energy reserve metabolic process
DNA methylation
regulation of transcription from RNA polymerase II promoter
post-embryonic development
positive regulation of sodium ion transport
positive regulation of cAMP biosynthetic process
embryonic hindlimb morphogenesis
multicellular organism growth
negative regulation of renal sodium excretion
post-embryonic body morphogenesis
response to drug
positive regulation of GTPase activity
skin development
positive regulation of cAMP-mediated signaling
positive regulation of osteoblast differentiation
positive regulation of osteoclast differentiation
negative regulation of blood pressure
embryonic cranial skeleton morphogenesis
cartilage development
calcium ion homeostasis
genetic imprinting
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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