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Invitrogen

GNAS (R201C Mutant) Polyclonal Antibody

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GNAS (R201C Mutant) Polyclonal Antibody

Product Details

PA5-119556

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide surrounding mutant R201C of mouse GNAS. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.96 mg/mL

Amount

96 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913129

Product Specific Information

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Information

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5530400H20Rik; A930027G11Rik; adenylate cyclase-stimulating G alpha protein; alpha stimulating) complex locus; alternative gene product encoded by XL-exon; C130027O20Rik; extra large alphas protein; G protein; G protein subunit alpha S; Galphas; GNAS (guanine nucleotide binding protein; GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; Gnas1; Gnasxl; GNSA1; GPSA; Gs alpha subunit; Gs-alpha; Gsa; GSP; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; guanine nucleotide-binding protein alpha subunit; Nesp; Nesp55; NESP55; large dense core vesicle secretory protein; Nespl; neuroendocrine secretory protein 55; NTas; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; SCG6; secretogranin VI; stimulatory G protein of adenylate cyclase, alpha chain; stimulatory G-protein alpha subunit; unnamed protein product; XL2

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Gene Aliases: 5530400H20Rik; A930027G11Rik; AHO; AIMAH1; C130027O20Rik; C20orf45; Galphas; GNAS1; Gnasxl; GPSA; Gs-alpha; GSA; GSP; NESP; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; PITA3; POH; SCG6; SgVI

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UniProt ID: (Human) O95467, (Mouse) P63094

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Entrez Gene ID: (Human) 2778, (Mouse) 14683

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Function(s)
GTPase activity obsolete small monomeric GTPase activity insulin-like growth factor receptor binding protein binding GTP binding adenylate cyclase activator activity guanyl nucleotide binding G-protein beta/gamma-subunit complex binding beta-2 adrenergic receptor binding D1 dopamine receptor binding mu-type opioid receptor binding ionotropic glutamate receptor binding corticotropin-releasing hormone receptor 1 binding G-protein alpha-subunit binding adenylate cyclase regulator activity protein domain specific binding G-protein beta-subunit binding alpha-tubulin binding alkylglycerophosphoethanolamine phosphodiesterase activity
Process(es)
skeletal system development cellular glucose homeostasis tissue homeostasis positive regulation of protein phosphorylation endochondral ossification energy reserve metabolic process regulation of transcription from RNA polymerase II promoter signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway adenylate cyclase-activating serotonin receptor signaling pathway sensory perception of chemical stimulus positive regulation of cell proliferation response to xenobiotic stimulus post-embryonic development regulation of signal transduction positive regulation of sodium ion transport regulation of skeletal muscle contraction response to prostaglandin E embryonic hindlimb morphogenesis multicellular organism growth positive regulation of insulin secretion involved in cellular response to glucose stimulus cell surface bile acid receptor signaling pathway negative regulation of multicellular organism growth post-embryonic body morphogenesis skin development positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation negative regulation of blood pressure developmental growth embryonic cranial skeleton morphogenesis positive regulation of phagocytosis cognition cartilage development bone development hair follicle placode formation platelet aggregation response to parathyroid hormone cellular response to glucagon stimulus cellular response to prostaglandin E stimulus cellular response to acidic pH genetic imprinting cellular response to catecholamine stimulus adenylate cyclase-activating adrenergic receptor signaling pathway positive regulation of cold-induced thermogenesis regulation of parathyroid hormone secretion ovarian follicle development negative regulation of inflammatory response to antigenic stimulus renal water homeostasis activation of adenylate cyclase activity female pregnancy sensory perception of smell protein secretion positive regulation of insulin secretion intracellular transport vascular endothelial cell response to laminar fluid shear stress
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