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Invitrogen
GNAT3 Polyclonal Antibody
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Product Details
PA5-50670
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues near the N terminal of human guanine nucleotide binding protein, alpha transducing 3
Conjugate
Form
Liquid
Concentration
1.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total GNAT3 protein.
Target Information
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-gustducin; guanine nucleotide binding protein, alpha transducing 3; Guanine nucleotide-binding protein G(t) subunit alpha-3; gustatory G protein; Gustducin alpha-3 chain; gustducin, alpha polypeptide
Gene Aliases: GDCA; Ggust; Gnat-3; GNAT3; Gtn
UniProt ID: (Human) A8MTJ3, (Mouse) Q3V3I2, (Rat) P29348
Entrez Gene ID: (Human) 346562, (Mouse) 242851, (Rat) 286924
protein folding
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
response to nicotine
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
detection of chemical stimulus involved in sensory perception of bitter taste
signal transduction
G-protein coupled receptor signaling pathway
metabolic process
sensory perception of taste
visual perception
detection of visible light
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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