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Product Details
15388-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
GNB3 Fusion Protein Ag7050 (3-340 aa encoded by BC002454) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.45 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: EMEQLRQEA EQLKKQIADA RKACADVTLA ELVSGLEVVG RVQMRTRRTL RGHLAKIYAM HWATDSKLLV SASQDGKLIV WDSYTTNKVH AIPLRSSWVM TCAYAPSGNF VACGGLDNMC SIYNLKSREG NVKVSRELSA HTGYLSCCRF LDDNNIVTSS GDTTCALWDI ETGQQKTVFV GHTGDCMSLA VSPDFNLFIS GACDASAKLW DVREGTCRQT FTGHESDINA ICFFPNGEAI CTGSDDASCR LFDLRADQEL ICFSHESIIC SITSVAFSLS GRLLFAGYDD FNCNVWDSMK SERVGILSGH DNRVSCLGVT ADGMAVATGS WDSFLKIWN (3-340 aa encoded by BC002454 )
Target Information
Heterotrimeric guanine nucleotide-binding proteins in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein beta-subunit; G protein, beta-3 subunit; gbb3; GTP-binding regulatory protein beta-3 chain; guanine nucleotide binding protein (G protein), beta 3; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide binding protein, beta 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; guanine nucleotide-binding protein, beta-3 subunit; hypertension associated protein; Transducin beta chain 3
Gene Aliases: CSNB1H; Gnb-3; GNB3
UniProt ID: (Human) P16520, (Mouse) Q61011, (Rat) P52287
Entrez Gene ID: (Human) 2784, (Mouse) 14695, (Rat) 60449
Molecular Function:
heterotrimeric G-protein
Performance Guarantee
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