Heterotrimeric guanine nucleotide-binding proteins in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
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Protein Aliases: G protein beta-subunit; G protein, beta-3 subunit; gbb3; GTP-binding regulatory protein beta-3 chain; guanine nucleotide binding protein (G protein), beta 3; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide binding protein, beta 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; guanine nucleotide-binding protein, beta-3 subunit; hypertension associated protein; Transducin beta chain 3
Gene Aliases: CSNB1H; Gnb-3; GNB3
Molecular Function: heterotrimeric G-protein