Proteintech

GNRHR Polyclonal Antibody

GNRHR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GNRHR Antibody (19950-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Mouse ovary tissue slide using (Product # 19950-1-AP) GNRHR antibody at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

GNRHR Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19950-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody only recognizes isoform 1 of GNRHR. The predicted unmodified molecular weight of the human GNRHR is ~38 kDa, the larger band (50-60 kDa) is likely to represent a glycosylated form of GNRHR.

Target Information

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Discovery of microglia gonadotropin‑releasing hormone receptor and its potential role in polycystic ovarian syndrome.

Molecular medicine reports

Wang F,Zhang Z,Han J,Zheng J,Wang X,Wang Z

Sat Apr 01 00:00:00 UTC 2023

Chemical profile and miscarriage prevention evaluation of Jiao-Ai Decoction, a classical traditional Chinese formula.

Journal of pharmaceutical and biomedical analysis

Zhang M,Geng T,Jing SH,Li L,Wang K,Zhang Q,Zhang Y,Zhou SK,Gao P,Ding AW,Zhang L

Fri Aug 05 00:00:00 UTC 2022

Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.

International journal of nanomedicine

Fu Y,Yuan P,Zheng Y,Wei Y,Gao L,Ruan Y,Chen Y,Li P,Feng W,Zheng X

Tue Apr 12 00:00:00 UTC 2022

Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.

International journal of nanomedicine

Fu Y,Yuan P,Zheng Y,Wei Y,Gao L,Ruan Y,Chen Y,Li P,Feng W,Zheng X

Tue Apr 12 00:00:00 UTC 2022

Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure.

Basic & clinical pharmacology & toxicology

Zheng S,Ma M,Chen Y,Li M

Tue Feb 01 00:00:00 UTC 2022

Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure.

Basic & clinical pharmacology & toxicology

Zheng S,Ma M,Chen Y,Li M

Tue Feb 01 00:00:00 UTC 2022

Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Fu Y,Yuan P,Zheng Y,Gao L,Wei Y,Chen Y,Li P,Ruan Y,Zheng X,Feng W

Wed Jun 01 00:00:00 UTC 2022

Impact of Physiologically Relevant Genistein Exposure at Different Time Windows on Puberty Onset and Neuroendocrine Function in Female Rats.

Molecular nutrition & food research

Xiong J,Tian Y,Ma G,Wang X,Shan S,Cheng G

Thu Dec 01 00:00:00 UTC 2022

Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates.

International journal of molecular sciences

Schuster S,Juhász É,Halmos G,Neundorf I,Gennari C,Mező G

Tue May 03 00:00:00 UTC 2022

GnRH receptor mediates lipid storage in female adipocytes via AMPK pathway.

International journal of medical sciences

Li X,Zhang X,Shen Z,Chen Z,Wang H,Zhang X

Tue Aug 30 00:00:00 UTC 2022

GnRH receptor mediates lipid storage in female adipocytes via AMPK pathway.

International journal of medical sciences

Li X,Zhang X,Shen Z,Chen Z,Wang H,Zhang X

Tue Aug 30 00:00:00 UTC 2022

Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation.

Frontiers in endocrinology

Guo Y,Wu Y,Shi J,Zhuang H,Ci L,Huang Q,Wan Z,Yang H,Zhang M,Tan Y,Sun R,Xu L,Wang Z,Shen R,Fei J

Tue Dec 21 00:00:00 UTC 2021

Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation.

Frontiers in endocrinology

Guo Y,Wu Y,Shi J,Zhuang H,Ci L,Huang Q,Wan Z,Yang H,Zhang M,Tan Y,Sun R,Xu L,Wang Z,Shen R,Fei J

Tue Dec 21 00:00:00 UTC 2021

The Effects of Zearalenone on the Localization and Expression of Reproductive Hormones in the Ovaries of Weaned Gilts.

Toxins

Wan B,Yuan X,Yang W,Jiao N,Li Y,Liu F,Liu M,Yang Z,Huang L,Jiang S

Tue Sep 07 00:00:00 UTC 2021

The Effects of Zearalenone on the Localization and Expression of Reproductive Hormones in the Ovaries of Weaned Gilts.

Toxins

Wan B,Yuan X,Yang W,Jiao N,Li Y,Liu F,Liu M,Yang Z,Huang L,Jiang S

Tue Sep 07 00:00:00 UTC 2021

GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes.

Scientific reports

Nicholas DA,Knight VS,Tonsfeldt KJ,Terasaka T,Molinar-Inglis O,Stephens SBZ,Trejo J,Kauffman AS,Mellon PL,Lawson MA

Mon Aug 03 00:00:00 UTC 2020

GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes.

Scientific reports

Nicholas DA,Knight VS,Tonsfeldt KJ,Terasaka T,Molinar-Inglis O,Stephens SBZ,Trejo J,Kauffman AS,Mellon PL,Lawson MA

Mon Aug 03 00:00:00 UTC 2020

GnRH antagonist treatment of malignant adrenocortical tumors.

Endocrine-related cancer

Doroszko M,Chrusciel M,Stelmaszewska J,Slezak T,Anisimowicz S,Plöckinger U,Quinkler M,Bonomi M,Wolczynski S,Huhtaniemi I,Toppari J,Rahman NA

Tue Jan 01 00:00:00 UTC 2019

GnRH antagonist treatment of malignant adrenocortical tumors.

Endocrine-related cancer

Doroszko M,Chrusciel M,Stelmaszewska J,Slezak T,Anisimowicz S,Plöckinger U,Quinkler M,Bonomi M,Wolczynski S,Huhtaniemi I,Toppari J,Rahman NA

Tue Jan 01 00:00:00 UTC 2019

Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.

International journal of molecular sciences

Ranđelović I,Schuster S,Kapuvári B,Fossati G,Steinkühler C,Mező G,Tóvári J

Wed Sep 25 00:00:00 UTC 2019

Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.

International journal of molecular sciences

Ranđelović I,Schuster S,Kapuvári B,Fossati G,Steinkühler C,Mező G,Tóvári J

Wed Sep 25 00:00:00 UTC 2019

Novel Crizotinib-GnRH Conjugates Revealed the Significance of Lysosomal Trapping in GnRH-Based Drug Delivery Systems.

International journal of molecular sciences

Murányi J,Varga A,Gyulavári P,Pénzes K,Németh CE,Csala M,Pethő L,Csámpai A,Halmos G,Peták I,Vályi-Nagy I

Fri Nov 08 00:00:00 UTC 2019

Novel Crizotinib-GnRH Conjugates Revealed the Significance of Lysosomal Trapping in GnRH-Based Drug Delivery Systems.

International journal of molecular sciences

Murányi J,Varga A,Gyulavári P,Pénzes K,Németh CE,Csala M,Pethő L,Csámpai A,Halmos G,Peták I,Vályi-Nagy I

Fri Nov 08 00:00:00 UTC 2019

Suitability of GnRH Receptors for Targeted Photodynamic Therapy in Head and Neck Cancers.

International journal of molecular sciences

Pethő L,Murányi J,Pénzes K,Gurbi B,Brauswetter D,Halmos G,Csík G,Mező G

Fri Oct 11 00:00:00 UTC 2019

The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.

Frontiers in endocrinology

Suo L,Chang X,Xu N,Ji H

Tue Feb 25 00:00:00 UTC 2020

Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids.

Beilstein journal of organic chemistry

Lajkó E,Spring S,Hegedüs R,Biri-Kovács B,Ingebrandt S,Mező G,Kőhidai L

Tue Sep 29 00:00:00 UTC 2020

Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids.

Beilstein journal of organic chemistry

Lajkó E,Spring S,Hegedüs R,Biri-Kovács B,Ingebrandt S,Mező G,Kőhidai L

Tue Sep 29 00:00:00 UTC 2020

Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification.

Pharmaceutics

Schuster S,Biri-Kovács B,Szeder B,Buday L,Gardi J,Szabó Z,Halmos G,Mező G

Fri Nov 09 00:00:00 UTC 2018

Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification.

Pharmaceutics

Schuster S,Biri-Kovács B,Szeder B,Buday L,Gardi J,Szabó Z,Halmos G,Mező G

Fri Nov 09 00:00:00 UTC 2018

Peptide-Drug Conjugate GnRH-Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth.

Cancer research

Argyros O,Karampelas T,Asvos X,Varela A,Sayyad N,Papakyriakou A,Davos CH,Tzakos AG,Fokas D,Tamvakopoulos C

Tue Mar 01 00:00:00 UTC 2016

Peptide-Drug Conjugate GnRH-Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth.

Cancer research

Argyros O,Karampelas T,Asvos X,Varela A,Sayyad N,Papakyriakou A,Davos CH,Tzakos AG,Fokas D,Tamvakopoulos C

Tue Mar 01 00:00:00 UTC 2016

Synthesis, characterization and systematic comparison of FITC-labelled GnRH-I, -II and -III analogues on various tumour cells.

Journal of peptide science : an official publication of the European Peptide Society

Murányi J,Gyulavári P,Varga A,Bökönyi G,Tanai H,Vántus T,Pap D,Ludányi K,Mező G,Kéri G

Mon Aug 01 00:00:00 UTC 2016

Synthesis, characterization and systematic comparison of FITC-labelled GnRH-I, -II and -III analogues on various tumour cells.

Journal of peptide science : an official publication of the European Peptide Society

Murányi J,Gyulavári P,Varga A,Bökönyi G,Tanai H,Vántus T,Pap D,Ludányi K,Mező G,Kéri G

Mon Aug 01 00:00:00 UTC 2016

Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus-Uterus in Pubertal Female Rats.

International journal of environmental research and public health

Liu T,Jia Y,Zhou L,Wang Q,Sun D,Xu J,Wu J,Chen H,Xu F,Ye L

Sat Nov 12 00:00:00 UTC 2016

Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus-Uterus in Pubertal Female Rats.

International journal of environmental research and public health

Liu T,Jia Y,Zhou L,Wang Q,Sun D,Xu J,Wu J,Chen H,Xu F,Ye L

Sat Nov 12 00:00:00 UTC 2016

Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus-Uterus in Pubertal Female Rats.

International journal of environmental research and public health

Liu T,Jia Y,Zhou L,Wang Q,Sun D,Xu J,Wu J,Chen H,Xu F,Ye L

Sat Nov 12 00:00:00 UTC 2016

Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus-Uterus in Pubertal Female Rats.

International journal of environmental research and public health

Liu T,Jia Y,Zhou L,Wang Q,Sun D,Xu J,Wu J,Chen H,Xu F,Ye L

Sat Nov 12 00:00:00 UTC 2016

GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.

Bioconjugate chemistry

Karampelas T,Argyros O,Sayyad N,Spyridaki K,Pappas C,Morgan K,Kolios G,Millar RP,Liapakis G,Tzakos AG,Fokas D,Tamvakopoulos C

Wed Apr 16 00:00:00 UTC 2014

GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.

Bioconjugate chemistry

Karampelas T,Argyros O,Sayyad N,Spyridaki K,Pappas C,Morgan K,Kolios G,Millar RP,Liapakis G,Tzakos AG,Fokas D,Tamvakopoulos C

Wed Apr 16 00:00:00 UTC 2014

Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary.

Endocrinology

Torrealday S,Lalioti MD,Guzeloglu-Kayisli O,Seli E

Tue Oct 01 00:00:00 UTC 2013

Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary.

Endocrinology

Torrealday S,Lalioti MD,Guzeloglu-Kayisli O,Seli E

Tue Oct 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: GnRH receptor; gnRH-R; gonadotropin-releasing hormone (type 1) receptor 1; Gonadotropin-releasing hormone receptor; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; Lh-rh receptor; luliberin receptor; type I GnRH receptor; Type I GNRHR1

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Gene Aliases: GNRHR; GNRHR1; GRHR; HH7; LHRHR; LRHR

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UniProt ID: (Human) P30968, (Mouse) Q01776

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Entrez Gene ID: (Human) 2798, (Mouse) 14715

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Function(s)

gonadotropin-releasing hormone receptor activity peptide binding signal transducer activity G-protein coupled receptor activity protein-hormone receptor activity growth hormone-releasing hormone receptor activity G-protein coupled receptor

Process(es)

G-protein coupled receptor signaling pathway multicellular organism development cellular response to gonadotropin-releasing hormone signal transduction negative regulation of cell proliferation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GNRHR Polyclonal Antibody

GNRHR Antibody (19950-1-AP) in IHC (P)

Product Details

19950-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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