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FIGURE: 1 / 1
Positive test controls include: BT-474, NCI-H460, 293T, SKOV3, HeLa, Mouse liver, Mouse kidney, Mouse spleen, Rat brain. The target is usually found in the following locations: Lysosome.
Immunogen sequence: WQTLLSVDDL VEKLVKRLEF TGELNNTYIF YTSDNGYHTG QFSLPIDKRQ LYEFDIKVPL LVRGPGIKPN QTSKMLVANI DLGPTILDIA GYDLNKTQMD GMSLLPILRG ASNLTWRSDV LVEYQGEGRN VTDPTCPSLS PGVSQCFPDC VCEDAYNNTY ACVRTMSALW NLQYCEFDDQ EVFVEVYNLT ADPDQITNIA KTIDPELLGK MNYRLMMLQS CSGPTCRTPG VFDPGYRFDP RLMFSNRGSV RTRRFSKHLL
GNS is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G6S; glucosamine -6-sulfatase; Glucosamine-6-sulfatase; N-acetylglucosamine-6-sulfatase
Gene Aliases: 2610016K11Rik; AU042285; C87209; G6S; GNS; N28088
UniProt ID: (Human) P15586, (Mouse) Q8BFR4
Entrez Gene ID: (Human) 2799, (Mouse) 75612, (Rat) 299825
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