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Proteintech
GOLPH3 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-19112
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GOLPH3 fusion protein Ag5443
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MTSLTQRSS GLVQRRTEAS RNAADKERAA GGGAGSSEDD AQSRRDEQDD DDKGDSKETR LTLMEEVLLL GLKDREGYTS FWNDCISSGL RGCMLIELAL RGRLQLEACG MRRKSLLTRK VICKSDAPTG DVLLDEALKH VKETQPPETV QNWIELLSGE TWNPLKLHYQ LRNVRERLAK NLVEKGVLTT EKQNFLLFDM TTHPLTNNNI KQRLIKKVQE AVLDKWVNDP HRMDRRLLAL IYLAHASDVL ENAFAPLLDE QYDLATKRVR QLLDLDPEVE CLKANTNEVL WAVVAAFTK
Target Information
GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin. GOLPH3 has since been implicated in the target of rapamycin (TOR) signaling pathway. Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF. Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signaling through TOR-associated complexes. These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coat protein GPP34; coat-protein; golgi peripheral membrane protein 1, 34 kDa; Golgi phosphoprotein 3; golgi phosphoprotein 3 (coat-protein); golgi protein; golgi-associated protein; MIDAS; Mitochondrial DNA absence factor; trans-Golgi protein GMx33
Gene Aliases: 4733401N08Rik; 5730410D03Rik; AW413496; Gmx33; GOLPH3; GOPP1; GPP34; MIDAS; Vps74
UniProt ID: (Human) Q9H4A6, (Mouse) Q9CRA5
Entrez Gene ID: (Human) 64083, (Mouse) 66629, (Rat) 78961
transport
Golgi organization
cell proliferation
glycoprotein biosynthetic process
protein secretion
gene expression
regulation of mitochondrion organization
protein transport
cell migration
lamellipodium assembly
positive regulation of TOR signaling
Golgi to plasma membrane protein transport
negative regulation of apoptotic process
protein retention in Golgi apparatus
Golgi vesicle budding
positive regulation of protein secretion
leukocyte tethering or rolling
cell adhesion molecule production
Golgi ribbon formation
asymmetric Golgi ribbon formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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