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Invitrogen
GPIHBP1 Polyclonal Antibody
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FIGURE: 1 / 2
GPIHBP1 Antibody (PA1-16977) in ICC/IF
Immunocytochemistry analysis of GPIHBP1 in HeLa cells. Samples were incubated with GPIHBP1 polyclonal antibody (Product # PA1-16977) followed by DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).
Product Details
PA1-16977
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to an internal region [within residues 170-250] of mouse GPIHBP1.
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: mouse kidney lysate or protein.
Target Information
GPI-anchored HDL-binding protein 1 (Gpihbp1) is a novel protein that may be involved in the regulation of the delivery of fats to cells for energy and storage. Digested fats travel to the small intestine, where they are packaged into chylomicrons (particles filled with triglycerides). Chylomicrons then travel through the bloodstream and deliver triglycerides to tissues that are hungry for fuel or to adipose tissue for energy storage. Triglycerides are broken down or hydrolyzed by the enzyme lipoprotein lipase (LpL). The triglyceride breakdown products are then taken up and used by cells. Gpihbp1 is the molecule in capillaries that facilitates the capture of chylomicrons and facilitates the interaction with LpL. It has been shown that fats in the bloodstream are not readily metabolized in the absence of GPIHBP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endothelial cell LPL transporter; Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; GPI anchored high density lipoprotein binding protein 1; GPI-anchored HDL-binding protein 1; GPI-HBP1; gpihbp1; HDLBP; HDLBP1; High density lipoprotein-binding protein 1
Gene Aliases: 1110002J19Rik; GPI-HBP1; GPIHBP1; HBP1; HYPL1D
UniProt ID: (Human) Q8IV16, (Mouse) Q9D1N2
Entrez Gene ID: (Human) 338328, (Mouse) 68453
transport
lipid transport
intracellular protein transport
protein import
cholesterol transport
protein localization to cell surface
cholesterol homeostasis
transcytosis
protein stabilization
positive regulation of lipoprotein lipase activity
triglyceride homeostasis
protein transmembrane transport
positive regulation of chylomicron remodeling
positive regulation of chylomicron remnant clearance
response to heparin
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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