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Proteintech
GPR105 Polyclonal Antibody
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Product Details
20190-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GPR105 Fusion Protein Ag14105 (249-338 aa encoded by BC034989)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YHIARIPYT KSQTEAHYSC QSKEILRYMK EFTLLLSAAN VCLDPIIYFF LCQPFREILC KKLHIPLKAQ NDLDISRIKR GNTTLESTDT L (249-338 aa encoded by BC034989)
Target Information
GPR105 has been reported to be expressed in brain. ESTs have been isolated from kidney, placenta, uterus, and heart/melanocyte/uterus libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G protein coupled receptor for UDP-glucose; G protein-coupled receptor 105; G protein-coupled receptor VTR 15-20; G-protein coupled receptor 105; GPCR105; P2Y purinoceptor 14; P2Y(14) receptor; P2Y14; P2Y14 receptor; purinergic receptor P2Y, G-protein coupled, 14; UDP-glucose receptor; VTR 15-20; VTR 15-20 receptor
Gene Aliases: A330108O13Rik; BPR105; GPR105; KIAA0001; P2RY14; P2Y14
UniProt ID: (Human) Q15391, (Mouse) Q9ESG6, (Rat) O35881
Entrez Gene ID: (Human) 9934, (Mouse) 140795, (Rat) 171108
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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