|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (2 ITLNNQDQPVPFNSSHPDEYK 22) of GPR18 protein.|
|Purification||Antigen affinity chromatography|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||3-6 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The G-protein-coupled receptor (GPCR, GPR) superfamily is the largest known receptor family and is characterized by seven transmembrane domains. GPCRs transduce a variety of extracellular signals such as photons, peptides, hormone proteins, neurotransmitters, amino acids, lipids, prostanoids, and odorants through heterotrimeric G-proteins. GPR18 is a member of this family consisting of 331 amino acids. The human GPR18 gene is localized in the chromosomal region 13q32.3. The protein has been reported to show moderate expression in brain, testis, ovary, and lung, high expression in lymphoid tissues such as spleen and thymus, and is involved in immune system regulation. N-arachidonyl glycine acts as a natural ligand for the protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.