|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human GPR18.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bat, Elephant, Horse, Rabbit, Pufferfish (100%).
The G-protein-coupled receptor (GPCR, GPR) superfamily is the largest known receptor family and is characterized by seven transmembrane domains. GPCRs transduce a variety of extracellular signals such as photons, peptides, hormone proteins, neurotransmitters, amino acids, lipids, prostanoids, and odorants through heterotrimeric G-proteins. GPR18 is a member of this family consisting of 331 amino acids. The human GPR18 gene is localized in the chromosomal region 13q32.3. The protein has been reported to show moderate expression in brain, testis, ovary, and lung, high expression in lymphoid tissues such as spleen and thymus, and is involved in immune system regulation. N-arachidonyl glycine acts as a natural ligand for the protein.