In IHC applications, antigen retrieval using Proteinase K treatment is recommended.
Percent identity with other species by BLAST analysis: Human, Gorilla, Marmoset, Elephant, Panda (100%) Mouse, Rat (94%) Opossum, Platypus (89%) Chicken, Xenopus (83%).
G protein coupled receptors (GPCRs) are a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins. The 375 amino acid GPCR GPR27 protein contains several features of the GPCR family, including 7 transmembrane domains, potential N linked glycosylation sites in the N terminal extracellular domain, and conserved cysteine residues, which may form a disulfide bridge, in the first and second extracellular loops.
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Protein Aliases: Probable G-protein coupled receptor 27; Super conserved receptor expressed in brain 1
Gene Aliases: GPR27; SREB1
UniProt ID: (Human) Q9NS67
Entrez Gene ID: (Human) 2850
Molecular Function: G-protein coupled receptor