Invitrogen

GPR30 Polyclonal Antibody

9 Published Figures
14 References
View all (45) GPR30 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-28647

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 7 publications 7 publications

Immunohistochemistry (IHC)

-
View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

C. elegans, Dog, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide encompassing a sequence within the Intracellular domain of human GPR30. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2546123

Product Specific Information

Recommended positive controls: unboiled GPER-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Chemoattractant receptor-like 2; chemokine receptor-like 2; constitutively expressed peptide-like receptor; constitutively expressed peptide-like receptor like; FEG-1; Flow-induced endothelial G-protein coupled receptor 1; G protein-coupled estrogen receptor 1; G protein-coupled receptor 30; G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; G-protein coupled receptor 41; GPCR-Br; heptahelix receptor; IL8-related receptor DRY12; leucine rich protein in GPR30 3'UTR; LYGPR; Lymphocyte-derived G-protein coupled receptor; Membrane estrogen receptor; mER

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Gene Aliases: 6330420K13Rik; CEPR; Ceprl; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER; GPER1; GPR30; GPR41; LERGU; LERGU2; LyGPR; mER

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UniProt ID: (Human) Q99527, (Rat) O08878, (Mouse) Q8BMP4

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Entrez Gene ID: (Human) 2852, (Rat) 171104, (Mouse) 76854

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Function(s)
chromatin binding G-protein coupled receptor activity steroid binding protein binding drug binding mineralocorticoid receptor activity estrogen receptor activity steroid hormone binding steroid hormone receptor activity hormone binding signal transducer activity G-protein coupled receptor
Process(es)
positive regulation of protein phosphorylation positive regulation of neurotransmitter secretion negative regulation of leukocyte activation inflammatory response cell cycle G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of cell cycle process positive regulation of phosphatidylinositol 3-kinase signaling neuronal action potential apoptotic chromosome condensation nuclear fragmentation involved in apoptotic nuclear change positive regulation of cell migration intracellular steroid hormone receptor signaling pathway positive regulation of cAMP biosynthetic process mineralocorticoid receptor signaling pathway positive regulation of insulin secretion positive regulation of inositol trisphosphate biosynthetic process positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process steroid hormone mediated signaling pathway positive regulation of MAPK cascade innate immune response negative regulation of fat cell differentiation positive regulation of epidermal growth factor receptor signaling pathway positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response positive regulation of neurogenesis negative regulation of DNA metabolic process negative regulation of lipid biosynthetic process positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of uterine smooth muscle contraction negative regulation of cell cycle arrest cellular response to glucose stimulus cellular response to tumor necrosis factor cellular response to peptide hormone stimulus cellular response to mineralocorticoid stimulus cellular response to estradiol stimulus positive regulation of establishment of protein localization to plasma membrane positive regulation of release of cytochrome c from mitochondria negative regulation of vascular smooth muscle cell proliferation positive regulation of endothelial cell apoptotic process positive regulation of cardiac vascular smooth muscle cell differentiation positive regulation of extrinsic apoptotic signaling pathway immune system process transcription from RNA polymerase II promoter apoptotic process signal transduction nervous system development cell differentiation
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