Immunogen sequence: MDVTSQARGV GLEMYPGTAQ RMQVDKKRVY LATDDPSLLK EAKTKYPNYE FISDNSISWS AGLHNRYTEN SLRGVILDIH FLSQADFLVC TFSSQVCRVA YEIMQTLHPD ASANFHSLDD IYYFGGQNAH NQIAIYAHQP RTADEIPMEP GDIIGVAGNH WDGYSKGVNR KLGRTGLYPS YKVREKIETV KYPTYPEAEK; Positive Samples: Mouse brain, Mouse heart, Rat brain; Cellular Location: Basolateral cell membrane, Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle membrane, Early endosome, Endoplasmic reticulum membrane, Golgi apparatus, Golgi apparatus membrane, Mitochondrion membrane, Multi-pass membrane protein, Nucleus, Recycling endosome, axon, cytoskeleton, dendrite, dendritic spine membrane, perinuclear region, postsynaptic cell membrane, postsynaptic density, synapse, trans-Golgi network
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.
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Protein Aliases: Chemoattractant receptor-like 2; chemokine receptor-like 2; constitutively expressed peptide-like receptor; constitutively expressed peptide-like receptor like; FEG-1; Flow-induced endothelial G-protein coupled receptor 1; G protein-coupled estrogen receptor 1; G protein-coupled receptor 30; G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; G-protein coupled receptor 41; GPCR-Br; heptahelix receptor; IL8-related receptor DRY12; leucine rich protein in GPR30 3'UTR; LYGPR; Lymphocyte-derived G-protein coupled receptor; Membrane estrogen receptor; mER
Gene Aliases: 6330420K13Rik; CEPR; Ceprl; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER; GPER1; GPR30; GPR41; LERGU; LERGU2; LyGPR; mER