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Invitrogen
GPR31 Polyclonal Antibody
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FIGURE: 1 / 1
GPR31 Antibody (PA3-037) in IHC (P)
Immunohistochemistry analysis of GPR31 was performed on human enteric ganglion tissue. To expose target proteins, antigen retrieval was performed by microwaving tissues for 20 minutes in 10mM sodium citrate buffer (pH 6.0). Tissue slides were probed with a GPR31 polyclonal antibody (Product # PA3-037) at a dilution of 1:3000, overnight at 4C in a humidified chamber. Tissues were washed, and detection was pe... View More
Product Details
PA3-037
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated Cys-TLRGKGQAAEPPDFNPRDSYS
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
IHC (P) analysis shows positive staining of GPR31 in human enteric ganglion.
Target Information
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding leads to activation of MAPK and NF-kappa-B pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 12-(S)-HETE acid receptor; 12-(S)-HETE receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; bA517H2.2 (G protein-coupled receptor 31); G-protein coupled receptor 31; GPR31/12-HETER; hydroxyeicosatetraenoic (HETE) acid receptor 1; probable G-protein coupled receptor 31; TCP10C
Gene Aliases: 12-HETER; GPR31; HETER; HETER1
UniProt ID: (Human) O00270
Entrez Gene ID: (Human) 2853
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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