|Immunohistochemistry (Paraffin) (IHC (P))||1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated Cys-TLRGKGQAAEPPDFNPRDSYS|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
IHC (P) analysis shows positive staining of GPR31 in human enteric ganglion.
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding leads to activation of MAPK and NF-kappa-B pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 10; 12-(S)-HETE acid receptor; 12-(S)-HETE receptor; 12-(S)-hydroxy-5; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; 12-HETER; 14-eicosatetraenoic acid receptor; 8; bA517H2.2 (G protein-coupled receptor 31); G protein-coupled receptor 31; G-protein coupled receptor 31; GPR31; hydroxyeicosatetraenoic (HETE) acid receptor 1; probable G-protein coupled receptor 31
Gene Aliases: 12-HETER; GPR31; HETER; HETER1
UniProt ID: (Human) O00270
Entrez Gene ID: (Human) 2853
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.