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Invitrogen
GPR37 Polyclonal Antibody
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FIGURE: 1 / 3
GPR37 Antibody (PA5-13413) in IHC (P)
Immunohistochemistry analysis of GPR37 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with GPR37 polyclonal antibody (Product # PA5-13413) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepa... View More
Product Details
PA5-13413
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human Pael-R (GPR37)
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Endothelin B receptor-like protein 1; ETBR-LP-1; G protein-coupled receptor 37 (endothelin receptor type B-like); G-protein coupled receptor 37; Gpcr/cns1; Het-b-r-lp; Pael receptor; PAELR; parkin-associated endothelin B-like receptor; Parkin-associated endothelin receptor-like receptor; probable G-protein coupled receptor 37; Prosaposin receptor GPR37
Gene Aliases: AI848630; EDNRBL; GPR37; hET(B)R-LP; Pael-R; PAELR
UniProt ID: (Human) O15354, (Mouse) Q9QY42
Entrez Gene ID: (Human) 2861, (Mouse) 14763
G-protein coupled receptor activity
protein binding
G-protein coupled peptide receptor activity
Hsp70 protein binding
heat shock protein binding
ubiquitin protein ligase binding
prosaposin receptor activity
peptide binding
signal transducer activity
G-protein coupled receptor
transmembrane signal receptor
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
locomotion involved in locomotory behavior
dopamine biosynthetic process
positive regulation of MAPK cascade
positive regulation of dopamine metabolic process
negative regulation of hydrogen peroxide-induced cell death
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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