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Product Details
14820-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:3,200 | View 5 publications 5 publications |
Immunocytochemistry (ICC/IF) |
Assay-dependent | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
GPR37/Pael-R Fusion Protein Ag6591 (34-264 aa encoded by BC040007) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.31 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
This antibody recognizes endogenous GPR37, which migrates as an approximately 50-55 kDa band in SDS-PAGE.
Immunogen sequence: SRNETCLGE SCAPTVIQRR GRDAWGPGNS ARDVLRARAP REEQGAAFLA GPSWDLPAAP GRDPAAGRGA EASAAGPPGP PTRPPGPWRW KGARGQEPSE TLGRGNPTAL QLFLQISEEE EKGPRGAGIS GRSQEQSVKT VPGASDLFYW PRRAGKLQGS HHKPLSKTAN GLAGHEGWTI ALPGRALAQN GSLGEGIHEP GGPRRGNSTN RRVRLKNPFY PLTQESYGAY AV (34-264 aa encoded by BC040007)
Target Information
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Endothelin B receptor-like protein 1; ETBR-LP-1; G protein-coupled receptor 37 (endothelin receptor type B-like); G-protein coupled receptor 37; G-protein coupled receptor CNS1; Gpcr/cns1; Het-b-r-lp; Pael receptor; PAELR; parkin-associated endothelin B-like receptor; Parkin-associated endothelin receptor-like receptor; probable G-protein coupled receptor 37; Prosaposin receptor GPR37
Gene Aliases: AI848630; EDNRBL; GPR37; hET(B)R-LP; Pael-R; PAELR
UniProt ID: (Human) O15354, (Mouse) Q9QY42, (Rat) Q9QYC6
Entrez Gene ID: (Human) 2861, (Mouse) 14763, (Rat) 117549
Molecular Function:
G-protein coupled receptor
transmembrane signal receptor
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
locomotion involved in locomotory behavior
dopamine biosynthetic process
positive regulation of MAPK cascade
positive regulation of dopamine metabolic process
negative regulation of hydrogen peroxide-induced cell death
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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