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Invitrogen
GPR40 Polyclonal Antibody
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Product Details
PA5-75351
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 201-250 of Human GPR40.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FFAR; Free fatty acid receptor 1; G protein-coupled receptor 40; G protein-coupled receptor GPR40; G-protein coupled receptor 40; HGNC:4498
Gene Aliases: FFA1R; FFAR1; GPCR40; GPR40
UniProt ID: (Human) O14842, (Rat) Q8K3T4, (Mouse) Q76JU9
Entrez Gene ID: (Human) 2864, (Rat) 266607, (Mouse) 233081
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
insulin secretion
positive regulation of insulin secretion
negative regulation of interleukin-1 beta production
glucose homeostasis
positive regulation of calcium ion transport
response to fatty acid
ligand-gated ion channel signaling pathway
positive regulation of calcium ion transport into cytosol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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