This antibody is predicted to react with bovine and rhesus monkey samples based on sequence homology.
Suggested positive control: antigen standard for GPR77 (transient overexpression lysate), human testis cell lysate, human testis protein.
Principal Names: G-protein coupled receptor 77 (GPCR77); C5a anaphylatoxin chemotactic receptor C5L2; GPF77; Official Gene Symbol: GPR77 Gen Bank Accession Number: NP_060955 Gene ID: 27202 (human) Gene Map Locus: 19q13.33 (human) C5L2 is 337A.A orphan member that belongs to anaphylatoxin receptor family. It is a seven transmembrane G-protein-coupled receptor consisting of an N-terminal N-glycosylation site, several conserved cysteines and several potential C-terminal phosphorylation sites. It binds to C5a and C5a-des-Arg and serves as a highly regulated scavenger receptor with a negative modulatory influence on C5aR-mediated inflammation. Northern Blot analysis suggests it is co- expressed along with C5aR in different tissues and cells including neutrophils/macrophages, mast cells, dendritic cells, brain, lung, heart, kidney, liver, ovary and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor C5L2; C5L2; Complement component 5a receptor 2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; G-protein coupled receptor 77; GPR77
Gene Aliases: C5AR2; C5L2; GPF77; GPR77
UniProt ID: (Human) Q9P296
Entrez Gene ID: (Human) 27202