GPR83, a 423 A.A protein, is an orphan member of GPCR protein family and is closely related to tachykinin and NPY receptors. It is a human homolog of mouse GIR protein and is exclusively expressed and selectively up-regulated in brain. It is a cell surface receptor protein consisting of a putative seven-transmembrane-domain. Reports suggest GPR83 might be involved in the regulation of immune tolerance mechanism by inducing peripheral generation of Foxp3+ Treg cells.
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Protein Aliases: G protein-coupled receptor 72; G-protein coupled receptor 72; glucocorticoid induced receptor; Glucocorticoid-induced receptor; Hcepto9; Jp05; Probable G-protein coupled receptor 83
Gene Aliases: AW045253; GIR; GPR72; GPR83; KIAA1540; RP105; RP39; RP82
Molecular Function: G-protein coupled receptor