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Alomone Labs, LTD
GPRC5B Polyclonal Antibody
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FIGURE: 1 / 3
GPRC5B Antibody (AGR-072-200UL) in IHC (F)
Expression of GPRC5B in mouse deep cerebellar nuclei. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections using Anti-GPRC5B Antibody (#AGR-072) (1:200), followed by goat anti-rabbit-AlexaFluor-488. A. GPRC5B immunoreactivity (green) appears in neuron outlines (arrows). B. Pre-incubation of the antibody with GPRC5B Blocking Peptide (BLP-GR072), suppressed staining. Cell nuclei are sta... View More
Product Details
AGR-072-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide DAHASNSSDGLGLND, corresponding to amino acids residues 191-205 of rat SLC6A3. Extracellular, 2nd loop.
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: DAHASNSSDGLGLND
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-69G12.1; G protein-coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 5, member B; G-protein coupled receptor family C group 5 member B; Gprc5b_v2; hypothetical protein, clone 2-63; RAIG-2; RAIG1 homolog; retinoic acid responsive gene protein; Retinoic acid-induced gene 2 protein; unnamed protein product
Gene Aliases: AW125761; GPRC5B; MLC3; RAIG-2; RAIG2
UniProt ID: (Human) Q9NZH0, (Mouse) Q923Z0
Entrez Gene ID: (Human) 51704, (Mouse) 64297, (Rat) 293546
cell volume homeostasis
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of neuron differentiation
positive regulation of inflammatory response
positive regulation of macrophage cytokine production
positive regulation of protein tyrosine kinase activity
positive regulation of canonical Wnt signaling pathway
positive regulation of protein phosphorylation
locomotory behavior
positive regulation of neuron projection development
glucose homeostasis
positive regulation of protein kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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