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GPRC5B Antibody (PA5-106843) in ICC/IF
Immunocytochemistry analysis of GPRC5B in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with GPRC5B polyclonal antibody (Product # PA5-106843) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-106843
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GPRC5B(Accession Q9NZH0), corresponding to amino acid residues A61-F111.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2854507
Product Specific Information
Antibody detects endogenous levels of total GPRC5B.
Target Information
This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-69G12.1; G protein-coupled receptor, class C, group 5, member B; G protein-coupled receptor, family C, group 1, member B; G-protein coupled receptor family C group 5 member B; RAIG-2; retinoic acid responsive gene protein; Retinoic acid-induced gene 2 protein
Gene Aliases: GPRC5B; RAIG-2; RAIG2
UniProt ID: (Human) Q9NZH0
Entrez Gene ID: (Human) 51704
G-protein coupled receptor signaling pathway
locomotory behavior
positive regulation of neuron projection development
activation of protein kinase activity
glucose homeostasis
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of neuron differentiation
positive regulation of inflammatory response
positive regulation of macrophage cytokine production
positive regulation of protein tyrosine kinase activity
positive regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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